ヒトの肝臓の形態形成についての論文 (Hirose et al) がAnatomical Recordsの Highlights記事で紹介されました.
AR Highlights
Embryonic Liver Morphology and Morphometry by Magnetic Resonance Microscopic Imaging by Ayumi Hirose, Takashi Nakashima, Shigehito Yamada, Chigako Uwabe, Katsumi Kose, and Tetsuya Takakuwa. Anat Rec 295:51–59
The liver plays an important role in the development of organs in the prenatal period. However, morphological and morphometric features of the liver during the early embryonic period are not well understood. Recent advances in medical imaging have enabled earlier assessment of human development in the first trimester. The authors carried out external morphologic and morphometric analysis of the liver during this period using a superparallel magnetic resonance microscope to image embryos obtained from the Kyoto Collection. They determined the external morphology as well as quantitative morphometry of the embryonic liver. They also found that development of the liver was greatly affected by adjacent organs and tissues. The data from this study provide a better understanding of liver development as well as morphogenesis of nearby organs. The authors’ results could also be used as a reference for clinical evaluation in the early stage of gestation, and this could be useful in fetal medicine and prenatal diagnosis. The authors predict that further improvement in imaging modalities will enable more precise detection of the intrahepatic vascular system.
5.Hamabe Y, Hirose A, Yamada S, Takakuwa T et al, Morphology and Morphometry of Fetal Liver at 16–26 Weeks of Gestation by Magnetic Resonance Imaging – Comparison with Embryonic Liver at Carnegie Stage 23, Hepatol Res,2013; 43: 639–647, doi: 10.1111/hepr.12000
Abstract
Aim
Normal liver growth was described morphologically and morphometrically using magnetic resonance imaging (MRI) data of human fetuses, and compared with embryonic liver to establish a normal reference chart for clinical use.
Methods
MRI images from 21 fetuses at 16–26 weeks of gestation and eight embryos at Carnegie stage (CS)23 were investigated in the present study. Using the image data, the morphology of the liver as well as its adjacent organs was extracted and reconstructed three-dimensionally. Morphometry of fetal liver growth was performed using simple regression analysis.
Results
The fundamental morphology was similar in all cases of the fetal livers examined. The liver tended to grow along the transversal axis. The four lobes were clearly recognizable in the fetal liver but not in the embryonic liver. The length of the liver along the three axes, liver volume and four lobes correlated with the bodyweight (BW). The morphogenesis of the fetal liver on the dorsal and caudal sides was affected by the growth of the abdominal organs, such as the stomach, duodenum and spleen, and retroperitoneal organs, such as the right adrenal gland and right kidney. The main blood vessels such as inferior vena cava, portal vein and umbilical vein made a groove on the surface of the liver. Morphology of the fetal liver was different from that of the embryonic liver at CS23.
Conclusion
The present data will be useful for evaluating the development of the fetal liver and the adjacent organs that affect its morphology.
4. Shiraishi N, Yamada S, Takakuwa T. Three-dimensional Models Once Again – for research and teaching of early human development, Congenit Anom (Kyoto), 2013; 53(1), 58-59, doi: 10.1002/ar.22662
Shiraishi N, Yamada S, Takakuwa T. Three-dimensional Models Once Again – for research and teaching of early human development, congenital anomaly, in press
2012 OARSI(Osteoarthritis Research Society International) world congressで修士2年藤岡さんが発表しました。
(April 26-29, 2012 Barcelona’s International Convention Centre (CCIB), Barcelona, Spain)
Analyses of cartilage superficial layer using immunohistochemical staining
Rune Fujioka, Tomoki Aoyama, Tetsuya Takakuwa, [.pdf]
2.Nakashima T, Hirose A, Yamada S, Uwabe C, Kose K, Takakuwa T, Morphometric analysis of the brain vesicles during the human embryonic period by magnetic resonance microscopic imaging, Congenit Anom (Kyoto). 2012 Mar;52(1):55-8, doi; 10.1111/j.1741-4520.2011.00345.x
ABSTRACT
The development of the brain vesicles between Carnegie stages (CS) 17 and 23 was analyzed morphometrically using 177 magnetic resonance image data derived from the Kyoto Collection of Human Embryos. Whole embryonic volume was 106.55 ± 21.08 mm3 at CS17, exponentially increasing to CS23 when it reached 1357.28 ± 392.20 mm3. Length of brain vesicles was 29.83 ± 2.52 mm at CS17, increased almost linearly and reached 49.31 ± 6.66 mm at CS23. The rate of increase was approximately 4.2 times higher on the dorsal side than on the ventral side. The increase in the length of the brain vesicles resulted mainly from that of the prosencephalon, and the rate of increase was three times higher on the dorsal side than on the ventral side of the prosencephalon.
