{"id":6503,"date":"2019-08-24T18:03:42","date_gmt":"2019-08-24T09:03:42","guid":{"rendered":"http:\/\/www.hs-kyoto.net\/?p=6503"},"modified":"2026-04-29T07:48:57","modified_gmt":"2026-04-28T22:48:57","slug":"%e9%88%b4%e6%9c%a8%e3%81%95%e3%82%93%e3%81%ae%e4%bf%ae%e5%a3%ab%e8%ab%96%e6%96%87%e3%81%8cplos-one%e3%81%ab%e5%8f%97%e8%ab%be","status":"publish","type":"post","link":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/?p=6503","title":{"rendered":"\u5927\u817f\u9aa8\u306f\u3001\u3069\u306e\u3088\u3046\u306b\u5f62\u6210\u3055\u308c\u308b\u306e\u304b"},"content":{"rendered":"\n<p>\u9234\u6728\u3055\u3093\u306f\u4fee\u58eb\u7814\u7a76\u3067\u3001\u30d2\u30c8\u80da\u306e<strong>\u5927\u817f\u9aa8<\/strong>\u304c\u80da\u671f\u304b\u3089\u65e9\u671f\u80ce\u5150\u671f\u306b\u304b\u3051\u3066\u3069\u306e\u3088\u3046\u306b\u5f62\u6210\u3055\u308c\u308b\u306e\u304b\u3092\u3001<strong>\u9ad8\u89e3\u50cf\u5ea6\u306e\u4e09\u6b21\u5143\u753b\u50cf\u89e3\u6790<\/strong>\u3092\u7528\u3044\u3066\u8a73\u3057\u304f\u8abf\u3079\u307e\u3057\u305f\u3002<br>\u305d\u306e\u7d50\u679c\u3001<strong>CS18<\/strong>\u3067\u8edf\u9aa8\u3068\u3057\u3066\u521d\u3081\u3066\u8a8d\u8b58\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u3001<strong>CS20<\/strong>\u3067\u306e\u521d\u671f\u306e\u9aa8\u5316\u304c\u59cb\u307e\u308b\u307e\u3067\u306e\u9593\u306b\u3001<strong>\u5927\u817f\u9aa8\u306e\u4e3b\u8981\u306a\u89e3\u5256\u5b66\u7684\u30e9\u30f3\u30c9\u30de\u30fc\u30af\u304c\u5f62\u6210\u3055\u308c\u308b<\/strong>\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<br>\u307e\u305f\u3001\u808b\u9aa8\u3084\u810a\u690e\u3068\u306e\u4f4d\u7f6e\u95a2\u4fc2\u304c\u5927\u817f\u9aa8\u306e\u6210\u9577\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3082\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u30012019\u5e748\u670823\u65e5\u306b\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u306e\u80cc\u666f<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"610\" height=\"463\" src=\"https:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/2019\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2026-04-29-7.44.22-610x463.png\" alt=\"\" class=\"wp-image-14656\" style=\"width:450px\" srcset=\"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/2019\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2026-04-29-7.44.22-610x463.png 610w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/2019\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2026-04-29-7.44.22-395x300.png 395w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/2019\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2026-04-29-7.44.22-115x87.png 115w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/2019\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2026-04-29-7.44.22-768x583.png 768w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/2019\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2026-04-29-7.44.22.png 1102w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/figure>\n<\/div>\n\n\n<p>\u5927\u817f\u9aa8\u306f\u3001\u30d2\u30c8\u306e\u4e0b\u80a2\u306e\u4e2d\u3067\u6700\u3082\u5927\u304d\u306a\u9aa8\u3067\u3042\u308a\u3001<strong>\u5185\u81d3\u306e\u4fdd\u8b77<\/strong>\u3084<strong>\u904b\u52d5\u6a5f\u80fd<\/strong>\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<br>\u5927\u817f\u9aa8\u306f\u3001\u80da\u671f\u306b\u306f\u307e\u305a<strong>\u9593\u8449\u7d44\u7e54\u306e\u51dd\u7e2e<\/strong>\u3068\u3057\u3066\u73fe\u308c\u3001\u305d\u306e\u5f8c<strong>\u8edf\u9aa8\u5316<\/strong>\u3092\u7d4c\u3066\u3001\u6700\u7d42\u7684\u306b\u306f<strong>\u5185\u56e0\u6027\u9aa8\u5316<\/strong>\u306b\u3088\u3063\u3066\u786c\u3044\u9aa8\u306b\u5909\u308f\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u306f\u3001\u5927\u817f\u9aa8\u306e\u9aa8\u5316\u4e2d\u5fc3\u304c\u51fa\u73fe\u3057\u305f\u5f8c\u306e\u767a\u9054\u904e\u7a0b\u306b\u7126\u70b9\u304c\u5f53\u3066\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u304f\u3001<strong>\u521d\u671f\u306e\u5f62\u614b\u5f62\u6210\u904e\u7a0b<\/strong>\u306b\u3064\u3044\u3066\u306f\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u90e8\u5206\u304c\u3042\u308a\u307e\u3057\u305f\u3002<br>\u7279\u306b\u3001<strong>\u5927\u817f\u9aa8\u306e\u6210\u9577\u3068\u5468\u56f2\u306e\u69cb\u9020\uff08\u808b\u9aa8\u3084\u810a\u690e\uff09\u3068\u306e\u95a2\u4fc2<\/strong>\u306b\u3064\u3044\u3066\u306f\u3001\u8a73\u7d30\u306a\u4e09\u6b21\u5143\u7684\u306a\u89e3\u6790\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305d\u3053\u3067\u672c\u7814\u7a76\u3067\u306f\u3001\u30d2\u30c8\u80da\u306e\u5927\u817f\u9aa8\u306e\u5f62\u614b\u5f62\u6210\u3092\u3001<strong>Carnegie stage\uff08CS\uff09\u3054\u3068\u306b<\/strong>\u4e09\u6b21\u5143\u7684\u306b\u89e3\u6790\u3057\u3001\u6210\u9577\u306e\u904e\u7a0b\u3092\u8a73\u3057\u304f\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u306e\u65b9\u6cd5<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u4eac\u90fd\u5927\u5b66\u306e<strong>\u4eac\u90fd\u30b3\u30ec\u30af\u30b7\u30e7\u30f3<\/strong>\u306b\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b<strong>CS17\u301cCS23\u306e\u30d2\u30c8\u80da62\u4f8b<\/strong>\u3092\u5bfe\u8c61\u306b\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002<br>\u753b\u50cf\u53d6\u5f97\u306b\u306f\u3001<strong>\u4f4d\u76f8\u5deeX\u7ddaCT\uff08PXCT\uff09\u3068MRI<\/strong>\u3092\u7528\u3044\u3001\u808b\u9aa8\u3084\u810a\u690e\u3068\u306e\u95a2\u4fc2\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u5404\u6a19\u672c\u306e\u808b\u9aa8\u3084\u810a\u690e\u306b\u5bfe\u3057\u3066\u3001<strong>84\u306e\u30e9\u30f3\u30c9\u30de\u30fc\u30af<\/strong>\u3092\u8a2d\u5b9a\u3057\u3001<strong>\u4e09\u6b21\u5143\u518d\u69cb\u7bc9<\/strong>\u3092\u884c\u3044\u307e\u3057\u305f\u3002<br>\u3055\u3089\u306b\u3001\u808b\u9aa8\u306e\u9577\u3055\u3084\u89d2\u5ea6\u3001\u305d\u3057\u3066\u5927\u817f\u9aa8\u306e\u9577\u3055\uff08ossified shaft length: OSL\uff09\u3092\u6e2c\u5b9a\u3057\u3001\u767a\u751f\u6bb5\u968e\u3054\u3068\u306e\u5909\u5316\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e3b\u306a\u7d50\u679c<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">1. \u5927\u817f\u9aa8\u306fCS18\u3067\u8edf\u9aa8\u3068\u3057\u3066\u521d\u3081\u3066\u8a8d\u8b58\u3055\u308c\u307e\u3057\u305f<\/h3>\n\n\n\n<p>\u89e3\u6790\u306e\u7d50\u679c\u3001<strong>CS18<\/strong>\u306e\u6bb5\u968e\u3067\u5927\u817f\u9aa8\u306f\u8edf\u9aa8\u3068\u3057\u3066\u660e\u77ad\u306b\u8a8d\u8b58\u3055\u308c\u3001<strong>CS20<\/strong>\u3067\u306f\u521d\u671f\u306e\u9aa8\u5316\u304c\u59cb\u307e\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<br>\u8edf\u9aa8\u306e\u5f62\u6210\u306f\u3001\u80da\u306e\u6210\u9577\u3068\u3068\u3082\u306b\u9032\u884c\u3057\u3001\u4e3b\u8981\u306a\u89e3\u5256\u5b66\u7684\u30e9\u30f3\u30c9\u30de\u30fc\u30af\u304c\u6b21\u7b2c\u306b\u660e\u78ba\u306b\u306a\u3063\u3066\u3044\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2. \u5927\u817f\u9aa8\u306e\u9577\u3055\u306f\u767a\u751f\u3068\u3068\u3082\u306b\u5897\u52a0\u3057\u307e\u3057\u305f<\/h3>\n\n\n\n<p>\u3059\u3079\u3066\u306e\u808b\u9aa8\u5bfe\u306b\u3064\u3044\u3066\u3001\u9577\u3055\u3092\u6e2c\u5b9a\u3057\u305f\u3068\u3053\u308d\u3001<strong>CS17\u3067\u306f\u5e73\u57473.05 mm<\/strong>\u304b\u3089\u59cb\u307e\u308a\u3001<strong>CS23\u3067\u306f22.56 mm<\/strong>\u306b\u9054\u3057\u307e\u3057\u305f\u3002<br>\u7279\u306b<strong>\u7b2c7\u808b\u9aa8<\/strong>\u3067\u6700\u3082\u9577\u304f\u306a\u308b\u50be\u5411\u304c\u898b\u3089\u308c\u3001\u808b\u9aa8\u306e\u6210\u9577\u304c\u80f8\u90ed\u5168\u4f53\u306e\u767a\u9054\u306b\u5927\u304d\u304f\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">3. \u5927\u817f\u9aa8\u306e\u5f62\u72b6\u306f\u3001\u4e3b\u306b2\u3064\u306e\u8981\u7d20\u3067\u8aac\u660e\u3067\u304d\u307e\u3057\u305f<\/h3>\n\n\n\n<p>\u4e3b\u6210\u5206\u5206\u6790\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u808b\u9aa8\u306e\u5f62\u72b6\u5909\u5316\u306f<strong>2\u3064\u306e\u4e3b\u6210\u5206<\/strong>\u3067\u8aac\u660e\u3067\u304d\u3001<strong>92.7%\u306e\u5909\u52d5\u3092\u30ab\u30d0\u30fc\u3057\u307e\u3057\u305f\u3002<br>\u7b2c1\u4e3b\u6210\u5206\u306f\u808b\u9aa8\u304c\u4f53\u5e79\u3092\u5305\u3080\u5f62<\/strong>\u3092\u793a\u3057\u3001\u7b2c2\u4e3b\u6210\u5206\u306f\u808b\u9aa8\u306e<strong>\u5916\u5074\u3078\u306e\u5f35\u308a\u51fa\u3057<\/strong>\u3092\u53cd\u6620\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">4. \u5927\u817f\u9aa8\u306e\u6210\u9577\u306f\u3001\u5468\u56f2\u306e\u81d3\u5668\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f<\/h3>\n\n\n\n<p>\u5927\u817f\u9aa8\u306e\u6210\u9577\u306f\u3001\u5fc3\u81d3\u3084\u809d\u81d3\u306a\u3069\u306e\u5185\u81d3\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u81d3\u5668\u304c\u767a\u751f\u306e\u904e\u7a0b\u3067\u3069\u306e\u3088\u3046\u306b\u4f4d\u7f6e\u3092\u5909\u3048\u308b\u304b\u304c\u3001\u808b\u9aa8\u306e\u5f62\u614b\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<br>\u7279\u306b\u3001\u5fc3\u81d3\u3068\u809d\u81d3\u306e\u4f4d\u7f6e\u306f\u3001\u767a\u751f\u306e\u5404\u6bb5\u968e\u3067\u808b\u9aa8\u306e\u6210\u9577\u3068\u76f8\u95a2\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">5. 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class=\"wp-block-heading\">\u3053\u306e\u7814\u7a76\u306e\u610f\u7fa9<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"610\" height=\"237\" src=\"https:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/2019\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2026-04-29-7.45.16-610x237.png\" alt=\"\" class=\"wp-image-14657\" style=\"width:450px\" srcset=\"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/2019\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2026-04-29-7.45.16-610x237.png 610w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/2019\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2026-04-29-7.45.16-400x156.png 400w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/2019\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2026-04-29-7.45.16-115x45.png 115w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/2019\/08\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2026-04-29-7.45.16.png 645w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/figure>\n<\/div>\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001\u30d2\u30c8\u80da\u306e\u5927\u817f\u9aa8\u5f62\u6210\u306b\u3064\u3044\u3066\u3001<strong>\u4e09\u6b21\u5143\u7684\u306b\u8a73\u7d30\u306b\u89e3\u6790\u3057\u305f\u7814\u7a76<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u306e\u6210\u679c\u304b\u3089\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5927\u817f\u9aa8\u306f<strong>CS18\u3067\u8edf\u9aa8\u3068\u3057\u3066\u521d\u3081\u3066\u8a8d\u8b58<\/strong>\u3055\u308c\u308b\u3053\u3068<\/li>\n\n\n\n<li><strong>CS20\u4ee5\u964d\u306b\u9aa8\u5316\u304c\u59cb\u307e\u308a\u3001\u808b\u9aa8\u3068\u306e\u95a2\u4fc2\u304c\u660e\u78ba\u306b\u306a\u308b<\/strong>\u3053\u3068<\/li>\n\n\n\n<li>\u5927\u817f\u9aa8\u306e\u6210\u9577\u306f<strong>\u5468\u56f2\u306e\u81d3\u5668\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b<\/strong>\u3053\u3068<\/li>\n\n\n\n<li>\u808b\u9aa8\u306e\u5f62\u614b\u306f<strong>\u5171\u901a\u306e\u767a\u751f\u30eb\u30fc\u30eb\u306b\u5f93\u3063\u3066\u9032\u884c\u3059\u308b<\/strong>\u3053\u3068<\/li>\n<\/ul>\n\n\n\n<p>\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u6b63\u5e38\u306a\u9aa8\u683c\u5f62\u6210\u306e\u7406\u89e3\u306b\u91cd\u8981\u3067\u3042\u308b\u3060\u3051\u3067\u306a\u304f\u3001<strong>\u9aa8\u5f62\u6210\u7570\u5e38\u3084\u5148\u5929\u6027\u75be\u60a3<\/strong>\u306e\u89e3\u660e\u306b\u3082\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u4eca\u5f8c\u306e\u5c55\u671b<\/h2>\n\n\n\n<p>\u4eca\u5f8c\u306f\u3001\u808b\u9aa8\u3068\u5927\u817f\u9aa8\u306e\u767a\u751f\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u3055\u3089\u306b\u8a73\u3057\u304f\u8abf\u3079\u308b\u305f\u3081\u306b\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7b4b\u8089\u3084\u95a2\u7bc0\u306e\u767a\u9054\u3068\u306e\u95a2\u9023<\/strong><\/li>\n\n\n\n<li><strong>\u4ed6\u306e\u81d3\u5668\u3068\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/li>\n\n\n\n<li><strong>\u767a\u751f\u7570\u5e38\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3092\u9032\u3081\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u308f\u308c\u308f\u308c\u306e\u7814\u7a76\u5ba4\u3067\u306f\u4eca\u5f8c\u3082\u3001\u30d2\u30c8\u80da\u306e\u9aa8\u683c\u5f62\u6210\u3092\u4e09\u6b21\u5143\u7684\u306b\u89e3\u6790\u3057\u3001\u6b63\u5e38\u767a\u751f\u3068\u7570\u5e38\u767a\u751f\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u8ad6\u6587\u60c5\u5831<\/h2>\n\n\n\n<p><strong>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb<\/strong><br><em>Morphogenesis of the femur at different stages of normal human development<\/em><\/p>\n\n\n\n<p><strong>\u8457\u8005<\/strong><br>Yuko Suzuki, Jun Matsubayashi, Xiang Ji, Shigehito Yamada, Akio Yoneyama, Hirohiko Imai, Tetsuya Matsuda, Tomoki Aoyama, Tetsuya Takakuwa<\/p>\n\n\n\n<p><strong>\u516c\u958b\u65e5<\/strong><br>2019\u5e748\u670823\u65e5<\/p>\n\n\n\n<p><strong>DOI<\/strong><br><a class=\"\" href=\"https:\/\/doi.org\/10.1371\/journal.pone.0221569\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1371\/journal.pone.0221569<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u3072\u3068\u3053\u3068<\/h2>\n\n\n\n<p 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