{"id":11685,"date":"2023-01-13T07:17:37","date_gmt":"2023-01-12T22:17:37","guid":{"rendered":"http:\/\/www.hs-kyoto.net\/?p=11685"},"modified":"2026-01-15T22:14:55","modified_gmt":"2026-01-15T13:14:55","slug":"2022%e5%b9%b4%e5%ba%a6-%e4%bf%ae%e5%a3%ab%e8%ab%96%e6%96%87%e6%a6%82%e8%a6%81","status":"publish","type":"post","link":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/?p=11685","title":{"rendered":"2022\u5e74\u5ea6; \u4fee\u58eb\u8ad6\u6587\u6982\u8981"},"content":{"rendered":"\n<p class=\"has-background\" style=\"background-color:#faf0c3;font-size:18px\"><strong>Three-dimensional analysis of the umbilical vein and the ductus venosus at the human embryonic and early fetal stages<br>\u30d2\u30c8\u80da\u5b50\u671f\u30fb\u80ce\u5150\u671f\u521d\u671f\u306b\u304a\u3051\u308b\u81cd\u5e2f\u9759\u8108\u3068\u9759\u8108\u7ba1\u306e3\u6b21\u5143\u7684\u89e3\u6790\u3000<br>\u78ef\u8c37\u3000\u83dc\u7a42\u5b50<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/pathology.hs.med.kyoto-u.ac.jp\/\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.26.01-610x709.png\" alt=\"\" style=\"width:300px;height:348px\"\/><\/figure>\n<\/div>\n\n\n<p>\u3010\u80cc\u666f\u3011\u81cd\u5e2f\u304b\u3089\u5fc3\u81d3\u307e\u3067\u306e\u9759\u8108\u7cfb\u77ed\u7d61\u8def\u306b\u3064\u3044\u3066\u306f\u3001\u9818\u57df\u306b\u3088\u3063\u3066\u3001\u767a\u751f\u6a5f\u5e8f\u3084\u51fa\u751f\u5f8c\u306e\u904b\u547d\u3001\u96a3\u63a5\u3059\u308b\u5668\u5b98\u3084\u6a5f\u80fd\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u9055\u3044\u306b\u3088\u308a\u3001\u3053\u306e\u77ed\u7d61\u8def\u306b\u306f\u9818\u57df\u3054\u3068\u306b\u5f62\u614b\u5b66\u7684\u3001\u7d44\u7e54\u5b66\u7684\u306a\u9055\u3044\u304c\u3042\u308b\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u77ed\u7d61\u8def\u5168\u4f53\u3092\u4fef\u77b0\u3059\u308b\u7dcf\u8ad6\u7684\u8996\u70b9\u3068\u3001\u9818\u57df\u3054\u3068\u306b\u5f62\u614b\u5b66\u7684\u7279\u5fb4\u3092\u691c\u8a0e\u3059\u308b\u5404\u8ad6\u7684\u306a\u8996\u70b9\u306e\u4e21\u9762\u304b\u3089\u5404\u9818\u57df\u306b\u304a\u3051\u308b\u5f62\u614b\u30fb\u8d70\u884c\u3084\u8840\u7ba1\u58c1\u306e\u7279\u5fb4\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<br>\u3010\u5bfe\u8c61\u30fb\u65b9\u6cd5\u3011\u4eac\u90fd\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u9644\u5c5e\u5148\u5929\u7570\u5e38\u6a19\u672c\u89e3\u6790\u30bb\u30f3\u30bf\u30fc\u4fdd\u6709\u306e\u30d2\u30c8\u80da\u5b50\u3001\u80ce\u5150\u671f\u521d\u671f\u6a19\u672c\u306e\u7acb\u4f53\u60c5\u5831\u8a0829\u4f8b\uff08\u4f4d\u76f8CT\uff1b18\u4f8b\uff08Carnegie stage(CS)15~23\uff09\u3001MRI\uff1b11\u4f8b\uff08\u982d\u6bbf\u9577(CRL)= 33mm~97mm\uff09\uff09\u3068\u30d2\u30c8\u80da\u5b50\u6a19\u672c\u306e\u9023\u7d9a\u7d44\u7e54\u5207\u7247\u753b\u50cf18\u4f8b\uff08CS15~23\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u4f4d\u76f8CT\u3001MRI\u306e\u753b\u50cf\u60c5\u5831\u3092\u3082\u3068\u306b\u77ed\u7d61\u8def\u306e\u7acb\u4f53\u50cf\u3092\u4f5c\u6210\u3057\u30011\uff09\u7acb\u4f53\u50cf\u306e\u89b3\u5bdf2\uff09\u8840\u7ba1\u5185\u8154\u306e\u5927\u304d\u3055\u3068\u5f62\u72b6\u306e\u53ef\u8996\u53163\uff09\u7a7a\u9593\u5ea7\u6a19\u3092\u7528\u3044\u305f\u8d70\u884c\u30fb\u5f62\u614b\u306e\u89e3\u67904\uff09\u5b9a\u91cf\u7684\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u7d44\u7e54\u5207\u7247\u753b\u50cf\u3092\u7528\u3044\u30665\uff09\u8840\u7ba1\u58c1\u306e\u7d44\u7e54\u5b66\u7684\u691c\u8a0e\u3092\u884c\u3063\u305f\u3002<br>\u3010\u7d50\u679c\u30111\uff09\u7acb\u4f53\u50cf\u306e\u89b3\u5bdf\uff1a\u81cd\u5e2f\u9759\u8108\u306f\u81cd\u5e2f\u8f2a\u304b\u3089\u809d\u81d3\u3078\u5411\u304b\u3063\u3066\u8d70\u884c\u3057\u3001\u809d\u81d3\u5185\u306e\u65b9\u5f62\u8449\u3068\u53f3\u8449\u306e\u5185\u4e0b\u9685\u3067\u3044\u304f\u3064\u304b\u306e\u5206\u679d\u3092\u751f\u3058\u305f\u3002\u809d\u5185\u81cd\u5e2f\u9759\u8108\u306f\u3055\u3089\u306b\u809d\u81d3\u5185\u3092\u8fd1\u4f4d\u65b9\u5411\u3078\u8d70\u884c\u3057\u3001\u809d\u81d3\u5c3e\u72b6\u8449\u306e\u5c3e\u5074\u7aef\u3067\u4e09\u80a1\u306b\u5206\u5c90\u3057\u305f\u3002\u3053\u306e\u9593\u3001\u81cd\u5e2f\u9759\u8108\u306e\u5206\u679d\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306f\u4f8b\u5916\u306a\u304fCS15\u304b\u3089CRL97mm\u307e\u3067\u89b3\u5bdf\u3055\u308c\u305f\u3002<br>2\uff09\u8840\u7ba1\u5185\u8154\u306e\u5927\u304d\u3055\u3068\u5f62\u72b6\u306e\u53ef\u8996\u5316\uff1aCS15~17\u3067\u306f\u81cd\u5e2f\u9759\u8108\u306e\u81cd\u5e2f\u8f2a\u5468\u56f2\u304c\u6700\u3082\u592a\u3044\u304c\u3001\u500b\u4f53\u304c\u6210\u9577\u3059\u308b\u3068\u809d\u81d3\u5185\u306e\u90e8\u5206\u3084\u4e0b\u5927\u9759\u8108\u306e\u90e8\u5206\u3078\u3068\u6700\u5927\u5185\u8154\u3092\u6301\u3064\u90e8\u5206\u306f\u5909\u5316\u3057\u305f\u3002\u81cd\u5e2f\u9759\u8108\u306fCS21\u9803\u3092\u5883\u306b\u5185\u8154\u304c\u4e0d\u5747\u4e00\u3067\u51f9\u51f8\u304c\u3042\u308b\u5f62\u614b\u304b\u3089\u6bd4\u8f03\u7684\u5186\u5f62\u3067\u5747\u4e00\u306a\u5f62\u614b\u3078\u5909\u5316\u3057\u305f\u3002<br>3\uff09\u7a7a\u9593\u5ea7\u6a19\u3092\u7528\u3044\u305f\u8d70\u884c\u30fb\u5f62\u614b\u306e\u89e3\u6790\uff1a\u77ed\u7d61\u8def\u306e\u81cd\u5e2f\u8f2a\u3084\u690e\u4f53\u3068\u306e\u4f4d\u7f6e\u95a2\u4fc2\u306f\u500b\u4f53\u306e\u6210\u9577\u306b\u3088\u3063\u3066\u8179\u8154\u5185\u3067\u5909\u5316\u3057\u3001\u80ce\u5150\u671f\u3067\u306f\u3088\u308a\u8179\u58c1\u306b\u8fd1\u3044\u4f4d\u7f6e\u3092\u8d70\u884c\u3059\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002\u77ed\u7d61\u8def\u306e\u8d70\u884c\u65b9\u5411\u306fCRL40mm\u9803\u307e\u3067\u306b\u6b63\u4e2d\u9762\u306b\u5e73\u884c\u3057\u3001CRL50mm\u9803\u304b\u3089\u306f\u5e73\u9762\u4e0a\u3067\u982d\u5c3e\u65b9\u5411\u3078\u7acb\u3061\u4e0a\u304c\u308b\u3088\u3046\u306a\u5909\u5316\u304c\u3042\u3063\u305f\u3002\u30d7\u30ed\u30af\u30e9\u30b9\u30c6\u30b9\u89e3\u6790\u3067\u306f\u81cd\u5e2f\u9759\u8108\u306e4\u3064\u306e\u5f62\u614b\u30d1\u30bf\u30fc\u30f3\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3001\u3053\u306e\u30d1\u30bf\u30fc\u30f3\u306f\u6210\u9577\u306b\u4f34\u3063\u3066\u5909\u5316\u3057\u305f\u3002<br>4\uff09\u5b9a\u91cf\u7684\u89e3\u6790\uff1a\u77ed\u7d61\u8def\u306e\u5168\u9577\u306f\u6210\u9577\u306b\u4f34\u3063\u3066\u5897\u52a0\u3057\u305f\u3002\u5168\u9577\u306b\u5bfe\u3059\u308b\u5404\u9818\u57df\u306e\u8840\u7ba1\u9577\u306e\u5272\u5408\u306b\u5927\u304d\u306a\u5909\u5316\u306f\u306a\u304f\u3001\u81cd\u5e2f\u9759\u8108\u304c50%\u4ee5\u4e0a\u3092\u5360\u3081\u305f\u304c\u3001\u809d\u5185\u3068\u809d\u5916\u306e\u8840\u7ba1\u5272\u5408\u306b\u306f\u5909\u5316\u304c\u3042\u3063\u305f\u3002\u6e7e\u66f2\u7387\u306f\u3069\u306e\u9818\u57df\u3067\u3082\u80da\u5b50\u671f\u306e\u5c0f\u3055\u3044\u500b\u4f53\u3067\u6bd4\u8f03\u7684\u306b\u9ad8\u3044\u50be\u5411\u306b\u3042\u3063\u305f\u3002\u9759\u8108\u7ba1\u306e\u6e7e\u66f2\u7387\u306fCRL10mm\u9803\u307e\u3067\u306b\u6025\u6fc0\u306b\u4f4e\u4e0b\u3057\u3001\u305d\u306e\u5f8c\u307b\u307c\u4e00\u5b9a\u3067\u3042\u3063\u305f\u3002<br>5\uff09\u8840\u7ba1\u58c1\u306e\u7d44\u7e54\u5b66\u7684\u691c\u8a0e\uff1a\u81cd\u5e2f\u9759\u8108\u3067\u306fCS20\u9803\u304b\u3089\u90e8\u5206\u306b\u3088\u3063\u3066\u8840\u7ba1\u58c1\u306e\u539a\u307f\u3084\u809d\u81d3\u3068\u306e\u63a5\u7740\u65b9\u6cd5\u306b\u9055\u3044\u304c\u898b\u3089\u308c\u305f\u3002\u9759\u8108\u7ba1\u306f\u307b\u3068\u3093\u3069\u306e\u90e8\u5206\u3067\u8840\u7ba1\u58c1\u304c\u8584\u3044\u304c\u3001CS20\u304b\u3089\u5165\u53e3\u90e8\u5206\u306b\u8840\u7ba1\u58c1\u306e\u9686\u8d77\u304c\u9650\u5c40\u7684\u306b\u898b\u3089\u308c\u305f\u3002 \u3010\u7d50\u8ad6\u3011\u81cd\u5e2f\u304b\u3089\u5fc3\u81d3\u307e\u3067\u306e\u9759\u8108\u7cfb\u77ed\u7d61\u8def\u306b\u3064\u3044\u3066\u3001\u5f62\u6210\u76f4\u5f8c\u3067\u3042\u308bCS15\u304b\u3089\u80ce\u5150\u671f\u521d\u671f\u306eCRL97mm\u307e\u3067\u7acb\u4f53\u50cf\u3092\u4f5c\u6210\u3057\u3001\u305d\u306e\u7d4c\u6642\u7684\u5909\u5316\u3092\u7dcf\u8ad6\u7684\u8996\u70b9\u3068\u5404\u8ad6\u7684\u306a\u8996\u70b9\u306e\u4e21\u9762\u304b\u3089\u5f62\u614b\u5b66\u7684\u3001\u5f62\u614b\u8a08\u6e2c\u5b66\u7684\u3001\u7d44\u7e54\u5b66\u7684\u306b\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n\n\n\n<p>67. Isotani N, Kanahashi T, Imai H, Yoneyama A, Yamada S, Takakuwa T. Regional differences in the umbilical vein and ductus venosus at different stages of normal human development. Anat Rec (Hoboken), 2024, 307, 3306-3326.DOI:10.1002\/ar.25421<\/p>\n\n\n\n<p class=\"has-background has-medium-font-size\" style=\"background-color:#faf0c3\"><strong>Morphogenesis of the pulmonary vein and the left atrial appendage in human embryos and early fetuses<br>\u30d2\u30c8\u80da\u5b50\u30fb\u80ce\u5150\u671f\u521d\u671f\u306b\u304a\u3051\u308b\u80ba\u9759\u8108\u30fb\u5de6\u5fc3\u8033\u306e\u5f62\u614b\u5f62\u6210\u3000<br>\u798f\u4e95\u3000\u6210\u7f8e<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"610\" height=\"492\" src=\"http:\/\/www.hs-kyoto.net\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.29.29-610x492.png\" alt=\"\" class=\"wp-image-11704\" style=\"width:300px;height:242px\" srcset=\"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.29.29-610x492.png 610w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.29.29-372x300.png 372w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.29.29-115x93.png 115w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.29.29-768x620.png 768w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.29.29-150x121.png 150w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.29.29-400x323.png 400w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.29.29.png 1142w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><\/figure>\n<\/div>\n\n\n<p>\u3010\u80cc\u666f\u3011\u5de6\u5fc3\u623f\u306f\u5fc3\u81d3\u5fc3\u5e95\u90e8\u306e\u5927\u90e8\u5206\u3092\u5f62\u6210\u3059\u308b\u3002\u5fc3\u5e95\u304b\u3089\u306f4 \u672c\u306e\u80ba\u9759\u8108\u304c\u6d41\u5165\u3057\u3001\u524d\u9762\u5074\u306b\u306f\u72ed\u7a84\u90e8\u3092\u4ecb\u3057\u3066\u5de6\u5fc3\u8033\u304c\u63a5\u5408\u3057\u3066\u3044\u308b\u3002\u767a\u751f4\u9031\u76ee\u672b\u9803\u3001\u5de6\u5fc3\u623f\u5f8c\u58c1\u304b\u3089\u7dcf\u80ba\u9759\u8108\u304c\u7a81\u51fa\u3059\u308b\u3002\u305d\u306e\u5f8c\u3001\u7dcf\u80ba\u9759\u8108\u30684\u672c\u306e\u80ba\u9759\u8108\u306e\u8fd1\u4f4d\u90e8\u306f\u62e1\u5f35\u3057\u3001\u5de6\u5fc3\u623f\u58c1\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001\u6700\u7d42\u7684\u306b4\u672c\u306e\u80ba\u9759\u8108\u304c\u5de6\u5fc3\u623f\u304b\u3089\u76f4\u63a5\u7a81\u51fa\u3059\u308b\u3002\u5de6\u5fc3\u8033\u306f\u539f\u59cb\u5de6\u5fc3\u623f\u306b\u7531\u6765\u3057\u3001\u767a\u751f4\u9031\u76ee\u306b\u5f62\u6210\u3055\u308c\u308b\u3002\u6210\u4eba\u306e\u5de6\u5fc3\u8033\u306f 1~4 \u3064\u306e\u5206\u8449\u69cb\u9020\u3092\u6301\u3061\u3001\u5185\u90e8\u306f\u6adb\u72b6\u7b4b\u306b\u3088\u3063\u3066\u6adb\u72b6\u69cb\u9020\u306b\u306a\u3063\u3066\u3044\u308b\u3002\u80ba\u9759\u8108\u306e\u53d6\u308a\u8fbc\u307f\u5b8c\u4e86\u6642\u671f\u306f\u6587\u732e\u306b\u3088\u3063\u3066\u69d8\u3005\u3067\u3042\u308a\u3001\u5de6\u5fc3\u8033\u306e\u5f62\u614b\u5f62\u6210\u306b\u3064\u3044\u3066\u306f\u6210\u4eba\u4f8b\u306e\u307f\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u3053\u3067\u3001\u9ad8\u89e3\u50cf\u5ea6\u306e\u753b\u50cf\u30c7\u30fc\u30bf\u3068 3 \u6b21\u5143\u60c5\u5831\u304b\u3089\u80ba\u9759\u8108\u306e\u53d6\u308a\u8fbc\u307f\u904e\u7a0b\u3068\u5de6\u5fc3\u8033\u306e\u767a\u751f\u306b\u3064\u3044\u3066\u691c\u8a0e\u3059\u308b\u3002 <\/p>\n\n\n\n<p>\u3010\u5bfe\u8c61\u3068\u65b9\u6cd5\u3011\u30d2\u30c8\u80da\u5b50\u6a19\u672c\u8a08 24 \u4f8b\u3001\u30d2\u30c8\u80ce\u5150\u6a19\u672c\u8a0820 \u4f8b\u3068\u3057\u305f\u3002\u4f4d\u76f8 CT \u64ae\u50cf\u3092\u884c\u3063\u3066\u53d6\u5f97\u3057\u305f CT \u753b\u50cf\u3068\u9ad8\u89e3\u50cf\u5ea6 MRI \u64ae\u50cf\u3092\u884c\u3063\u3066\u53d6\u5f97\u3057\u305f MR \u753b\u50cf\u4e0a\u3067\u3001\u80ba\u9759\u8108\u3092\u89b3\u5bdf\u3057\u305f\u3002MR \u753b\u50cf\u3092\u3082\u3068\u306b\u5fc3\u81d3\u90e8\u5206\u306e\u7acb\u4f53\u50cf\u3092\u518d\u69cb\u7bc9\u3057\u3001\u80ba\u9759\u8108\u3068\u5de6\u5fc3\u8033\u306e\u5f62\u614b\u5b66\u7684\u89b3\u5bdf\u3068\u5b9a\u91cf\u7684\u8a55\u4fa1\u3092\u884c\u3063\u305f\u3002<\/p>\n\n\n\n<p>\u3010\u7d50\u679c\u3011\u89b3\u5bdf\u3055\u308c\u305f\u80ba\u9759\u8108\u306e\u672c\u6570\u306f\u3001CS17~18 \u3067 1 \u672c\u3001CS18~21 \u3067 2 \u672c\u307e\u305f\u306f 4 \u672c\u3001CS22\u4ee5\u964d\u3067 3 \u672c\u307e\u305f\u306f 4 \u672c\u3067\u3042\u3063\u305f\u3002\u80ba\u9759\u8108\u304c 2 \u672c\u4ee5\u4e0a\u3042\u308b\u6a19\u672c\u3067\u306f\u3001CRL\u306e\u5897\u52a0\u306b\u4f34\u3044\u3001 \u5de6\u53f3\u306e\u80ba\u9759\u8108\u306e\u8ddd\u96e2\u304c\u9577\u304f\u306a\u308a\u3001\u5de6\u53f3\u306e\u80ba\u9759\u8108\u9593\u306e\u5de6\u5fc3\u623f\u306e\u539a\u307f\u3082\u5897\u52a0\u3057\u305f\u3002\u4e0a\u4e0b\u306e\u80ba\u9759\u8108\u9593\u306e\u8ddd\u96e2\u306f\u5de6\u53f3\u306e\u80ba\u9759\u8108\u9593\u306e\u8ddd\u96e2\u3088\u308a\u3082\u8fd1\u304b\u3063\u305f\u3002\u80ba\u9759\u8108\u304c 2 \u672c\u306e\u5834\u5408\u3001\u80ba\u9759\u8108\u306f\u80cc\u5074\u304b\u3089\u5de6\u5fc3\u623f\u5185\u306b\u6d41\u5165\u3057\u3001\u80ba\u9759\u8108\u304c 3 \u672c\u307e\u305f\u306f 4 \u672c\u306e\u5834\u5408\u3001\u80ba\u9759\u8108\u306f\u5de6\u5fc3\u623f\u3078\u80cc\u5074\u306e\u5916\u5074\u304b\u3089\u5185\u5074\u3078\u63a5\u7dda\u65b9\u5411\u306b\u5165\u308a\u8fbc\u3093\u3060\u3002\u80ba\u9759\u8108\u306e\u65ad\u9762\u7a4d\u306b\u3064\u3044\u3066\u306f\u3001\u5de6\u4e0a\u80ba\u9759\u8108\u304c\u6700\u3082\u5c0f\u3055\u3044\u50be\u5411\u306b\u3042\u308a\u3001\u4ed6\u306e3 \u672c\u306e\u80ba\u9759\u8108\u306f\u985e\u4f3c\u3057\u3066\u3044\u305f\u3002\u5f62\u72b6\u306f\u5de6\u4e0a\u80ba\u9759\u8108\u304c\u6700\u3082\u6241\u5e73\u3067\u3042\u308a\uff0c\u4ed6\u306e 3 \u3064\u306e\u80ba\u9759\u8108\u306f\u985e\u4f3c\u3057\u3066\u3044\u305f\u3002\u5de6\u5fc3\u8033\u306e\u6700\u3082\u539a\u307f\u306e\u3042\u308b\u90e8\u5206\u306f\u4e2d\u5fc3\u4ed8\u8fd1\u3067\u3042\u308a\u3001\u305d\u3053\u304b\u3089\u653e\u5c04\u72b6\u306b\u8584\u304f\u306a\u3063\u305f\u3002\u5de6\u5fc3\u8033\u306e\u958b\u53e3\u90e8\u306f CRL\u306e\u5897\u52a0\u306b\u4f34\u3044\u65ad\u9762\u7a4d\u304c\u5897\u5927\u3057\u3001\u6241\u5e73\u5316\u3059\u308b\u50be\u5411\u306b\u3042\u3063\u305f\u3002<\/p>\n\n\n\n<p>\u3010\u7d50\u8ad6\u3011\u80ba\u9759\u8108\u306e\u53d6\u308a\u8fbc\u307f\u306f CS18 \u9803\u304b\u3089\u59cb\u307e\u308a\u3001CS18~22 \u3067\u5b8c\u4e86\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u5de6\u4e0a\u80ba\u9759\u8108\u306e\u8fd1\u4f4d\u90e8\u306f\u4ed6\u306e 3 \u3064\u306e\u80ba\u9759\u8108\u3088\u308a\u65ad\u9762\u7a4d\u306f\u5c0f\u3055\u304f\u3001\u3088\u308a\u6241\u5e73\u3067\u3042\u308b\u3002\u80da\u5b50\u671f\u5f8c\u671f\u3088\u308a\u30013 \u672c\u307e\u305f\u306f 4 \u672c\u306e\u80ba\u9759\u8108\u306f\u5916\u5074\u3088\u308a\u5de6\u5fc3\u623f\u306b\u6d41\u5165\u3057\u3001\u5de6\u53f3\u306e\u80ba\u9759\u8108\u3088\u308a\u4e0a\u4e0b\u306e\u80ba\u9759\u8108\u9593\u306e\u8ddd\u96e2\u306e\u307b\u3046\u304c\u8fd1\u3044\u3002\u5de6\u5fc3\u8033\u306f\u4e2d\u5fc3\u4ed8\u8fd1\u304c\u6700\u3082\u539a\u304f\u3001\u305d\u3053\u304b\u3089\u653e\u5c04\u72b6\u306b\u8584\u304f\u306a\u3063\u3066\u3044\u304f\u3002\u5de6\u5fc3\u8033\u306e\u958b\u53e3\u90e8\u306f CRL \u306b\u4f34\u3044\u65ad\u9762\u7a4d\u304c\u5897\u5927\u3057\u3001\u6241\u5e73\u5316\u3059\u308b\u3002<\/p>\n\n\n\n[Background] The left atrium (LA) forms the bulk of the cardiac fundus. Four pulmonary veins (PVs) flow from the fundus, and the left appendage (LAA) is joined to the anterior side via a stenosis. Toward the end of the fourth week of development, the common pulmonary vein (CPV) protrudes from the posterior wall of the LA. The CPV and the proximal portions of the four PVs dilate and are taken up by the LA wall, and finally, the four PVs protrude directly from the left atrium. The LAA originates from the primordial LA and forms during the fourth week of development. The adult LAA has one to four lobe-like structures, and the interior of the LAA has a comb-like structure created by pectinate muscles. The time of completion of the PV uptake into the LA wall has been controversial in previous studies, and morphogenesis of the LAA has been reported only in adult cases. We provided the data showing the PV uptake process and the LAA development based on high-resolution image data and three-dimensional information.<br>[Materials &amp; Methods] Twenty-four human embryos and twenty fetuses were selected for this study. The PV was observed on CT images obtained by phase CT imaging and MR images obtained by high-resolution MRI imaging. 3D images of the heart portion were reconstructed based on the MR images, and morphological observation and quantitative evaluation of the PVs and LAA were performed.<br>[Results] The number of PV was one from CS 17 to CS 18, two or four from CS 18 to CS 21, and three or four after CS 22. In specimens with two or more PVs, the distance between the left and right PVs increased with CRL, as did the reconstruction of the LA thickness between the left and right-sided PV. The distance between the superior and inferior PVs was closer than between the left and right-sided PVs. When there were two PVs from CS18 to CS 21, they flowed into the LA from the dorsal side; when there were three or four PVs, they entered tangentially into the dorsal part of the LA from the lateral to medial direction. Regarding the cross-sectional area of the PV, the LSPV was the smallest, while the other three PVs were similar. In shape, the LSPV was the most flattened; the other three PVs were similar. The LAA thickness was thickest near the center, and it became radially thinner from there. The LAA orifice increased in area and tended to become more flattened with CRL.<br>[Conclusion] The PV uptake is thought to begin around CS 18 and complete from CS 18 to CS 22. The proximal portion of the LSPV is smaller in cross-sectional area and circumference than the other three PVs and is more flattened. Four PVs enter tangentially into the dorsal part of the LA from the lateral to medial direction. And the distance between the superior and inferior PV is closer than between the left and right-sided PV. The LAA thickness is thickest near the center, and it becomes radially thinner from there. The LAA orifice is found to increase in area and become more flattened with CRL.<\/p>\n\n\n\n<p>61. Fukui N, Kanahashi T, Matsubayashi J, Imai H, Yoneyama A, Otani H, Yamada S, Takakuwa T. Morphogenesis of the pulmonary vein and left atrial appendage in human embryos and early fetuses. J Anatomy 2023, in press,&nbsp;<a href=\"https:\/\/doi.org\/10.1111\/joa.13941\">https:\/\/doi.org\/10.1111\/joa.13941<\/a><\/p>\n\n\n\n<p class=\"has-background\" style=\"background-color:#faf0c3;font-size:19px\"><strong>Three-dimensional imaging analysis of developmental process of posterior meniscofemoral ligament in rat embryo<br>\u30e9\u30c3\u30c8\u80ce\u4ed4\u306b\u304a\u3051\u308b\u5f8c\u534a\u6708\u5927\u817f\u976d\u5e2f\u306e\u767a\u751f\u6a5f\u5e8f\u306e\u4e09\u6b21\u5143\u7684\u89e3\u6790 <br>\u77f3\u7530\u304b\u306e\u3093<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"528\" height=\"652\" src=\"http:\/\/www.hs-kyoto.net\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.27.51.png\" alt=\"\" class=\"wp-image-11705\" style=\"width:300px;height:369px\" srcset=\"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.27.51.png 528w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.27.51-243x300.png 243w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.27.51-93x115.png 93w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.27.51-121x150.png 121w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2023-01-13-20.27.51-400x494.png 400w\" sizes=\"auto, (max-width: 528px) 100vw, 528px\" \/><\/figure>\n<\/div>\n\n\n<p>\u3010\u76ee\u7684\u3011\u819d\u95a2\u7bc0\u306e\u5f8c\u534a\u6708\u5927\u817f\u976d\u5e2f(pMFL)\u306f\u3001\u819d\u95a2\u7bc0\u5b89\u5b9a\u3078\u306e\u5bc4\u4e0e\u3084\u5186\u76e4\u72b6\u5916\u5074\u534a\u6708\u677f\uff08DLM\uff09\u3068\u306e\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u5065\u5e38\u306a\u819d\u306b\u304a\u3051\u308b\u305d\u306e\u767a\u751f\u904e\u7a0b\u306f\u8abf\u67fb\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u672c\u7814\u7a76\u3067\u306f\u4e8c\u6b21\u5143\u7684\u306a\u767a\u751f\u904e\u7a0b\u306e\u89b3\u5bdf\u306b\u52a0\u3048\u3066\u4e09\u6b21\u5143\u518d\u69cb\u6210\u50cf\u3092\u7528\u3044\u305f\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u502b\u7406\u7684\u5236\u7d04\u306e\u305f\u3081\u3001\u30d2\u30c8\u3068\u819d\u306e\u69cb\u9020\u304c\u985e\u4f3c\u3057\u3001\u8907\u6570\u306e\u80ce\u4ed4\u3092\u5f97\u3089\u308c\u308b\u30e9\u30c3\u30c8\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u30e9\u30c3\u30c8\u819d\u95a2\u7bc0\u306epMFL\u306e\u767a\u751f\u904e\u7a0b\u3092\u4e09\u6b21\u5143\u7684\u306b\u89e3\u6790\u3057\u3001\u4ed6\u306e\u819d\u95a2\u7bc0\u69cb\u6210\u4f53\u3068\u306e\u95a2\u4fc2\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002<br>\u3010\u65b9\u6cd5\u3011\u80ce\u751f\u671f16\u65e5\u76ee\uff5e21\u65e5\u76ee(E16\uff5eE21)\u306eWistar\u30e9\u30c3\u30c8\u306e\u5f8c\u80a2\u306e\u5f62\u614b\u3068\u4f4d\u7f6e\u3092HE\u67d3\u8272\u3067\u78ba\u8a8d\u3057\u305f\u3002\u6b21\u306b\u3001\u81ea\u5bb6\u86cd\u5149\u3092\u753b\u50cf\u5316\u3059\u308bepiscopic fluorescence image capture (EFIC)\u306b\u3088\u3063\u3066\u3001E17\uff5eE21\u306e\u305d\u308c\u305e\u308c\u306b\u3064\u3044\u3066\u9023\u7d9a\u753b\u50cf\u3092\u64ae\u5f71\u3057\u305f\u3002\u4e09\u6b21\u5143\u50cf\u306e\u518d\u69cb\u6210\u3068\u8a08\u6e2c\u306f\u4e09\u6b21\u5143\u753b\u50cf\u89e3\u6790\u30bd\u30d5\u30c8Amira\u3067\u884c\u3063\u305f\u3002pMFL\u306e\u9577\u3055\u3001\u305f\u308f\u307f\u3001\u89d2\u5ea6\u3001\u4f53\u7a4d\u3092\u6e2c\u5b9a\u3057\u305f\u3002\u524d\u5341\u5b57\u976d\u5e2f(ACL)\u3001\u5f8c\u5341\u5b57\u976d\u5e2f(PCL)\u3001\u534a\u6708\u677f\u306e\u4f53\u7a4d\u3082\u6e2c\u5b9a\u3057\u3001pMFL\u3092\u542b\u3080\u5404\u69cb\u6210\u4f53\u306eE17\u306e\u5e73\u5747\u5024\u306b\u5bfe\u3059\u308b\u4f53\u7a4d\u306e\u5272\u5408\u3092\u6bd4\u8f03\u3057\u305f\u3002<br>\u3010\u7d50\u679c\u3011pMFL\u306fE17\u304b\u3089\u89b3\u5bdf\u3055\u308c\u3001\u5168\u6bb5\u968e\u3067\u5927\u817f\u9aa8\u5185\u5074\u9846\u3068\u5916\u5074\u534a\u6708\u677f\u306b\u4ed8\u7740\u3057\u3066\u3044\u305f\u3002pMFL\u306e\u9577\u3055\u53ca\u3073\u5404\u819d\u95a2\u7bc0\u69cb\u6210\u4f53\u306e\u4f53\u7a4d\u306fE19\uff5eE21\u306e\u9593\u306b\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\u304c\u3001pMFL\u306e\u305f\u308f\u307f\u3068\u89d2\u5ea6\u306b\u306f\u5168\u6bb5\u968e\u3092\u901a\u3057\u3066\u6709\u610f\u306a\u5909\u52d5\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u4f53\u7a4d\u306e\u5272\u5408\u306f\u3001E19\u307e\u3067\u5168\u3066\u306e\u69cb\u6210\u4f53\u304c\u540c\u7a0b\u5ea6\u306e\u5897\u52a0\u50be\u5411\u3092\u793a\u3057\u305f\u304c\u3001E20\u4ee5\u964d\u306f\u534a\u6708\u677f\u3068PCL\u304c\u9855\u8457\u306b\u5897\u52a0\u3057\u305f\u3002<br>\u3010\u8003\u5bdf\u3011pMFL\u306e\u9577\u3055\u3084\u5404\u69cb\u6210\u4f53\u306e\u4f53\u7a4d\u304cE19\u4ee5\u964d\u306b\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\u306e\u306b\u5bfe\u3057\u3001\u89d2\u5ea6\u306e\u5909\u52d5\u304c\u5bfe\u8c61\u671f\u9593\u3092\u901a\u3057\u3066\u5c11\u306a\u304b\u3063\u305f\u3053\u3068\u306f\u3001pMFL\u3068\u5468\u56f2\u306e\u69cb\u6210\u4f53\u304c\u4f4d\u7f6e\u95a2\u4fc2\u3092\u4fdd\u3061\u306a\u304c\u3089\u767a\u9054\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3002pMFL\u304c\u5927\u817f\u9aa8\u306b\u4ed8\u7740\u3059\u308b\u4f4d\u7f6e\u304c\u9ad8\u3044\u3068DLM\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u4eca\u56de\u306e\u7d50\u679c\u306fDLM\u306e\u767a\u751f\u6a5f\u5e8f\u306e\u7406\u89e3\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u307e\u305f\u3001\u30e9\u30c3\u30c8\u306e\u5f8c\u80a2\u904b\u52d5\u304cE16\uff5eE19\u306e\u9593\u306b\u5897\u52a0\u3059\u308b\u3068\u306e\u5831\u544a\u3068\u6bd4\u8f03\u3059\u308b\u3068pMFL\u306e\u9577\u3055\u3068\u5404\u69cb\u6210\u4f53\u306e\u4f53\u7a4d\u304c\u9855\u8457\u306b\u5897\u52a0\u3059\u308b\u6642\u671f\u306f\u3053\u308c\u306e\u76f4\u5f8c\u306b\u3042\u305f\u308a\u3001\u767a\u751f\u904e\u7a0b\u306f\u4e8c\u6bb5\u968e\u306b\u5206\u304b\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u30e9\u30c3\u30c8\u306f\u30d2\u30c8\u3068\u8377\u91cd\u306e\u304b\u304b\u308a\u65b9\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u30d2\u30c8\u819d\u306b\u304a\u3051\u308b\u767a\u751f\u904e\u7a0b\u306b\u3064\u3044\u3066\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <br>\u3010\u7d50\u8ad6\u3011\u30e9\u30c3\u30c8\u306epMFL\u53ca\u3073\u819d\u95a2\u7bc0\u69cb\u6210\u4f53\u306e\u767a\u751f\u904e\u7a0b\u3092\u4e09\u6b21\u5143\u7684\u306b\u89e3\u6790\u3057\u305f\u3002\u672c\u7814\u7a76\u306f\u6b63\u5e38\u306apMFL\u53ca\u3073\u819d\u95a2\u7bc0\u69cb\u6210\u4f53\u306e\u767a\u751f\u904e\u7a0b\u3092\u63d0\u793a\u3057\u3001\u89e3\u5256\u306e\u3088\u308a\u826f\u3044\u7406\u89e3\u306b\u8ca2\u732e\u3059\u308b\u3002<\/p>\n\n\n\n<p>Objectives: The posterior meniscofemoral ligament (pMFL) of the knee joint has been reported to contribute to knee joint stability and to be associated with the discoid lateral meniscus (DLM); however, its developmental process in healthy knees has not been studied. In this study, we analyzed the developmental process using three-dimensional (3D) reconstructed images in addition to two-dimensional observations. Owing to ethical constraints, rats were selected for this study because of the advantage of their similar knee structure to humans and the availability of multiple fetuses. The purpose of this study was to analyze pMFL development in rat knee joints three-dimensionally and examine its relationship with other knee joint components.<br>Methods: The shape and position of hindlimbs of Wistar rats at E16-E21 were confirmed with HE-stained tissue sections. Serial episcopic fluorescence images of the hindlimbs of E17-E21 were respectively captured by episcopic fluorescence image capture (EFIC), from which 3D images were reconstructed using Amira software. The pMFL length, deflection, angle, and volume were measured in 3D images. The volumes of the anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), and menisci were also measured and the ratio of the volume to the mean value at E17 of each component, including pMFL, was compared.Results: pMFL was observed from E17 and was attached to the medial femoral condyle and lateral meniscus at all stages. The pMFL length and volume of each knee joint component increased significantly between E19 and E21; no significant variation was observed in the pMFL deflection and angle throughout all phases. The Volume ratios showed that all components showed similar increasing trends until E19, but the menisci and PCL increased significantly from E20.<br>Discussion: While the length of pMFL and volume of each component increased significantly after E19, there was little variation in angle throughout the stages studied, suggesting that the pMFL and surrounding components developed with a positional relationship. A higher attachment position of the pMFL to the femur may cause DLM , and the present results may help in understanding the mechanism of DLM development. When compared with a report that hindlimb movement in rats increases between E16 and E19, the time when the length of pMFL and volume of each component significantly increased is just after this, indicating that the developmental process is divided into two phases. As rat knees are loaded differently from human knees, further studies are required on the developmental process of human knees.<br>Conclusion: The developmental process of pMFL and knee joint components in rat embryos was analyzed three-dimensionally. This study improves our understanding of the developmental processes of the normal pMFL and knee joint components.<\/p>\n\n\n\n<p>Tanima M, Ishida K, Ishikawa A, Yamada S, Takakuwa T, Aoyama T, Three-dimensional imaging analysis of the developmental process of posterior meniscofemoral ligaments in rat embryos. Cells Tissues Organs 2024, in press, DOI: 10.1159\/000536108<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Three-dimensional analysis of the umbilical vein and the ductus venosus at the human embryonic and early fetal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":11702,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36,19],"tags":[],"class_list":["post-11685","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-36","category-19"],"_links":{"self":[{"href":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/11685","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11685"}],"version-history":[{"count":19,"href":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/11685\/revisions"}],"predecessor-version":[{"id":14095,"href":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/11685\/revisions\/14095"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/index.php?rest_route=\/wp\/v2\/media\/11702"}],"wp:attachment":[{"href":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11685"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}