{"id":10267,"date":"2021-08-18T13:17:16","date_gmt":"2021-08-18T04:17:16","guid":{"rendered":"http:\/\/www.hs-kyoto.net\/?p=10267"},"modified":"2022-08-18T18:35:21","modified_gmt":"2022-08-18T09:35:21","slug":"differntial-growth%e3%81%8bmigration%e3%81%8b-%e7%99%ba%e7%94%9f%e3%81%ab%e4%bc%b4%e3%81%86%e8%a7%a3%e5%89%96%e5%ad%a6%e7%9a%84%e9%83%a8%e4%bd%8d%e3%81%ae%e7%a7%bb%e5%8b%95","status":"publish","type":"post","link":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/?p=10267","title":{"rendered":"Differntial growth\u304bMigration\u304b-\u767a\u751f\u306b\u4f34\u3046\u89e3\u5256\u5b66\u7684\u90e8\u4f4d\u306e\u79fb\u52d5"},"content":{"rendered":"\n

\u3000\u53e4\u5178\u7684\u306a\u767a\u751f\u89e3\u5256\u5b66\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u5f62\u614b\u5b66\u7684\u7279\u5fb4\u306f\u3001\u89b3\u5bdf\u8005\u304c\u5f97\u305f\u611f\u899a\u7684\u306a\u3082\u306e\u3092\u542b\u3093\u3067\u3044\u308b\u3002\u305d\u306e\u4ee3\u8868\u7684\u306a\u3082\u306e\u3068\u3057\u3066\u89e3\u5256\u5b66\u7684\u90e8\u4f4d\u306e\u2018\u79fb\u52d5\u2019\u304c\u3042\u308b\u3002\u2018\u79fb\u52d5\u2019\u306f\u3001\u672c\u5f53\u306b\u79fb\u52d5\u3059\u308b\u5834\u5408(migration)\u3068\u3001\u504f\u5dee\u6210\u9577\u306e\u7d50\u679c\u79fb\u52d5\u3057\u305f\u3088\u3046\u306b\u898b\u3048\u308b\u5834\u5408(differential growth)\u304c\u3042\u308a\u3001\u767a\u751f\u671f\u306e\u5668\u5b98\u306e\u79fb\u52d5\u306e\u591a\u304f\u306f\u3001differential growth\u3067\u8aac\u660e\u3067\u304d\u3001Migration\u3067\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u6b21\u306b\u793a\u3059\u3001\u521d\u6b69\u7684\u306a\u591a\u5143\u89e3\u5256\u5b66\u7684\u89e3\u6790\u3092\u7528\u3044\u305f\u5916\u8033\u3001\u773c\u7403\u306e\u79fb\u52d5\u306b\u3064\u3044\u3066\u306e\u89e3\u6790\u306fdifferential growth\u306b\u3064\u3044\u3066\u65b0\u305f\u306a\u77e5\u898b\u3092\u4e0e\u3048\u305f\u4f8b\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\u5916\u8033\u306e\u79fb\u52d5<\/h4>\n\n\n
\n
\"\"
\u56f3\uff11 \u5916\u8033\u306e\u79fb\u52d5<\/figcaption><\/figure>\n<\/div>\n\n\n

\u3000\u300e\u80da\u5b50\u671f\u306b\u5916\u8033\u306f\u9854\u306e\u5074\u65b9\u3092\u982d\u5074\u306b\u79fb\u52d5\u3057\u3066\u884c\u304f\u300f\u3068\u3001\u591a\u304f\u306e\u767a\u751f\u5b66\u306e\u6559\u79d1\u66f8\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u52d5\u304d\u306f\u201d\u79fb\u52d5 (migration)\u201d\u3067\u306f\u306a\u304f \u201d\u5206\u5316\u30fb\u6210\u9577 (differential growth)\u201d \u3067\u8aac\u660e\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u3001MRI\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u500b\u4f53\u306e\u4e2d\u5fc3\u306b\u57fa\u6e96\u70b9\u3092\u304a\u304d\u3001\u4f4d\u7f6e\u5909\u5316\u306e\u7d76\u5bfe\u5024\u3092\u691c\u8a0e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000\u65b9\u6cd5; MR\u9855\u5fae\u93e1\u3092\u7528\u3044\u3066\u64ae\u50cf\u3055\u308c\u305fCarnegie Stage (CS)17-23\u306b\u5206\u985e\u3055\u308c\u308b171\u4f8b\u306e\u80da\u5b50\u753b\u50cf\u3092\u7528\u3044\u305f\u3002\u89e3\u5256\u5b66\u7684\u76ee\u5370(\u5de6\u53f3\u5916\u8033(\u8033\u73e0)\u3001\u773c\u3001\u53e3\u3001\u4e0b\u5782\u4f53\u3001\u7b2c\uff11\u9838\u690e)\u3092\u9078\u629c\u3057MR\u753b\u50cf\u4e0a\u30673\u6b21\u5143\u5ea7\u6a19\u3092\u8a08\u6e2c\u3057\u30012\u7a2e\u985e\u306e\u5ea7\u6a19\u7cfb(-1, 2)\u3092\u7528\u3044\u3066\u4f4d\u7f6e\u5909\u5316\u3092\u8868\u793a\u3057\u305f\uff08\u56f3\uff11A\uff09\u3002<\/p>\n\n\n\n

\u3000\u5ea7\u6a19\u7cfb-1: \u500b\u4f53\u306e\u4e2d\u5fc3\u306b\u57fa\u6e96\u70b9\u3092\u7f6e\u304d\u7d76\u5bfe\u7684\u8ddd\u96e2\u3067\u8868\u793a (\u4f4d\u7f6e\u5909\u5316\u304c\u5206\u5316\u30fb\u6210\u9577\u306b\u3088\u308b\u304b\u3001\u79fb\u52d5\u306b\u3088\u308b\u304b\u3092\u898b\u5206\u3051\u308b\u65b9\u6cd5) \u3002\u7b2c\uff11\u9838\u690e-\u4e0b\u5782\u4f53\u3092\u901a\u308b\u76f4\u7dda\u3092\u57fa\u6e96 (z\u8ef8)\u3068\u3057\u305f\u3002\u3053\u308c\u306f\u4f53\u8ef8\u3092\u6c7a\u5b9a\u3059\u308b\u810a\u7d22\u306e\u8d70\u884c\u306b\u307b\u307c\u4e00\u81f4\u3059\u308b\u3002\u9854\u306e\u5927\u304d\u3055\u306e\u7d76\u5bfe\u5024\u3092\u7dad\u6301\u3057\u305f\uff08\u6210\u9577\u306b\u3088\u308b\u88dc\u6b63\u3092\u3057\u306a\u3044\uff09<\/p>\n\n\n\n

\u3000\u5ea7\u6a19\u7cfb-\uff12: \u8868\u9762\u306b\u57fa\u6e96\u70b9\u3092\u7f6e\u304d\u76f8\u5bfe\u7684\u8ddd\u96e2\u3067\u8868\u793a (\u8089\u773c\u7684\u4f53\u8868\u89b3\u5bdf\u3092\u518d\u73fe\u3059\u308b\u65b9\u6cd5)\u3002\u773c\u3001\u4e0b\u5782\u4f53\u3092\u901a\u308b\u5e73\u9762\u3092\u57fa\u6e96(xy\u5e73\u9762)\uff08\u9854\u3092\u6b63\u9762\u304b\u3089\u89b3\u5bdf\u3059\u308b\u305f\u3081\uff09\u3001\u53e3\u3068xy\u5e73\u9762\u306e\u8ddd\u96e2\u3092\u4e00\u5b9a(=1)\u306b\u306a\u308b\u3088\u3046\u306b\u8868\u3057\u3001\u9854\u306e\u5927\u304d\u3055\u3092\u76f8\u5bfe\u5316\u3057\u305f\u3002<\/p>\n\n\n\n

\u7d50\u679c\uff1b\u5916\u8033\u306f\u9854\u3092\u69cb\u6210\u3059\u308b\u4ed6\u306e\u89e3\u5256\u5b66\u7684\u76ee\u5370\uff08\u773c\u3001\u53e3\uff09\u3084\u4e0b\u5782\u4f53\u3068\u7570\u306a\u308a\u3001CS\u306e\u9032\u884c\u3057\u3066\u3082\u982d\/\u5c3e\u3001\u80cc\/\u8179\u8ef8\u65b9\u5411\u306e\u539f\u70b9(\u981a\u690eC1)\u304b\u3089\u306e\u4f4d\u7f6e\u5909\u5316\u306f\u6bd4\u8f03\u7684\u3086\u308b\u3084\u304b\u3067\u3042\u3063\u305f\uff08\u56f3\uff11B_a\uff09\u3002\u56f3\u306b\u306f\u793a\u3057\u3066\u3044\u306a\u3044\u304c\u3001\u6b63\u9762\u304b\u3089\u307f\u308b\u3068CS\u306e\u9032\u884c\u306b\u4f34\u3044\u3001\u5916\u8033\u306f\u4ed6\u306e\u89e3\u5256\u5b66\u7684\u76ee\u5370\u3068\u540c\u69d8\u3001\u539f\u70b9\u304b\u3089\u96e2\u308c\u3066\u3044\u3063\u305f\u3002\u5916\u8033\u306e\u4f4d\u7f6e\u5909\u5316\u304c\u773c\u3001\u53e3\u7b49\u3068\u7570\u306a\u308b\u306e\u306f\u3001\u4e21\u8005\u304c\u7570\u306a\u308b\u9854\u9762\u539f\u57fa\u306b\u7531\u6765\u3059\u308b\u305f\u3081\u3068\u601d\u308f\u308c\u308b\u3002\u5ea7\u6a19\u7cfb\u2212\uff12\u306b\u5f93\u3063\u3066\u8868\u793a\u3059\u308b\u3068\u3001\u5916\u8033\u306fCS\u304c\u3059\u3059\u3080\u3068\u3001\u5c3e\u5074\u304b\u3089\u5927\u304d\u304f\u79fb\u52d5\u3057CS23\u3067\u306f\u53e3\u3068\u982d\u3068\u306e\u9593\u306b\u4f4d\u7f6e\u3057\u305f(\u56f3\uff11B_b)\u3002<\/p>\n\n\n\n

\u3000\u4e21\u8005\u306e\u898b\u3048\u65b9\u306e\u9055\u3044\u3092\u8003\u5bdf\u3059\u308b\u305f\u3081\u306b\u3001\u80da\u5b50\u306e\u500d\u7387\u3092\u5909\u3048\u305a\u306b\u5ea7\u6a19\u7cfb-1\u3001\u2212\uff12\u306e\u8ef8\u306e\u95a2\u4fc2\u3092\u793a\u3057\u305f(\u56f3\uff11C)\u3002\u5ea7\u6a19\u7cfb-1\u306e\u8ef8(\u2192)\u3068-2\u306e\u8ef8(\u2192)\u306fCS\u304c\u3059\u3059\u3080\u306b\u3064\u308c\u3066\u4e56\u96e2\u3057\u3066\u3044\u304f\u3001\u3064\u307e\u308a\u9854\u9762\u3092\u6b63\u9762\u304b\u3089\u307f\u308b\u305f\u3081\u306e\u89b3\u5bdf\u65b9\u5411\u306f\u5927\u304d\u304f\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308b\u3002\u3053\u308c\u306f\u3001\u984e\u306e\u767a\u9054\u3001\u982d\u84cb\u5e95\u306e\u5f62\u6210\u306e\u5f71\u97ff\u306b\u3088\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002C1,\u4e0b\u5782\u4f53\u3068\u5916\u8033\u306e\u4f4d\u7f6e\u95a2\u4fc2\u306f\u3001CS\u3092\u901a\u3058\u3066\u307b\u307c\u5909\u5316\u3057\u306a\u3044\u3002\u4e00\u65b9\u3001\u5b9f\u969b\u306e\u8089\u773c\u5916\u8868\u89b3\u5bdf\u3067\u306f\u3001\u5ea7\u6a19\u7cfb-2\u306e\u3088\u3046\u306b\u3001\u76ee\u3084\u53e3\u3068\u3044\u3063\u305f\u9854\u306e\u8868\u9762\u306b\u3042\u308b\u89e3\u5256\u5b66\u7684\u57fa\u6e96\u3092\u3082\u3068\u306b\u76f8\u5bfe\u7684\u306a\u52d5\u304d\u3068\u3057\u3066\u5916\u8033\u306e\u4f4d\u7f6e\u3092\u3068\u3089\u3048\u308b\u305f\u3081\u79fb\u52d5\u3057\u3066\u898b\u3048\u308b\u306e\u3067\u3042\u308d\u3046\u3002\u53e4\u5178\u7684\u89e3\u6790\u3067\u306freference point\u3092\u6a19\u672c\u306e\u4e2d\u5fc3\u306b\u8fd1\u3044\u5185\u90e8\u306b\u3068\u308b\u3053\u3068\u304c\u56f0\u96e3\u3067\u3042\u3063\u305f\u3002\u672c\u7814\u7a76\u306f\u3001\u7acb\u4f53\u60c5\u5831\u306e\u9577\u6240\uff1a\u5916\u8868\u306e\u70b9\u3068\u5185\u90e8\u306e\u69cb\u9020\u3068\u3092\u9023\u52d5\u3067\u304d\u308b\u3001\u8907\u6570\u306e\u6642\u671f\u306e\u7570\u306a\u308b\u500b\u4f53\u3092\u540c\u4e00\u7e2e\u5c3a\u3067\u91cd\u306d\u5408\u308f\u305b\u3089\u308c\u308b\u3068\u3044\u3046\u9577\u6240\u3092\u6301\u3064\u3001\u3092\u6d3b\u304b\u3057\u305f\u89e3\u6790\u65b9\u6cd5\u3068\u3044\u3048\u308b\u3002<\/p>\n\n\n

\n
\"\"
\u56f3\uff12 \u30d2\u30c8\u80ce\u5150\u306e\u773c\u7403\u306e\u4f4d\u7f6e\u306e\u5909\u5316(CS17\u301c\u80ce\u5150\u671f\u521d\u671f\uff09\u70b9\u7dda\u306f\u982d\u84cb\u5e95\uff08\u5de6\u53f3\u306e\u55c5\u7403\u3068\u4e0b\u5782\u4f53\u5f8c\u8449\u306e\u4e0b\u7aef\u3092\u542b\u3080\u5e73\u9762\uff09\u3092\u8868\u3059\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

\u8996\u899a\u5668\u306e\u4f4d\u7f6e\u306e\u79fb\u52d5<\/strong><\/h2>\n\n\n\n

\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u30d2\u30c8\u80da\u5b50\u671f\u3001\u80ce\u5150\u671f\u521d\u671f\u306e\u500b\u4f53\uff08CRL12-85\u339c\uff09\u3092\u4f4d\u76f8CT\u3001MRI\u3067\u64ae\u50cf\u3057\u305f\u753b\u50cf\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u982d\u90e8\u306b\u304a\u3051\u308b\u6c34\u6676\u4f53\u30fb\u773c\u7403\u306e\u7acb\u4f53\u7684\u4f4d\u7f6e\u95a2\u4fc2\u306e\u5909\u5316\u306b\u3064\u3044\u30663\u6b21\u5143\u5ea7\u6a19\u3092\u7528\u3044\u3066\u691c\u8a0e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000\u982d\u90e8\u306b\u304a\u3051\u308b\u773c\u7403\u306e\u4f4d\u7f6e\u306e\u5909\u5316 (\u56f3\uff12)\u306f\u3001 CS17\u3067\u5916\u5074\u3092\u5411\u3044\u3066\u3044\u305f\u773c\u7403\u306f\u3001\u5f90\u3005\u306b\u8179\u5074\u3078\u79fb\u52d5\u3057\u3001\u80ce\u5150\u671f\u521d\u671f\u3067\u306f\u6210\u4eba\u3068\u307b\u307c\u540c\u3058\u65b9\u5411\uff08\u524d\u65b9\uff09\u3092\u5411\u3044\u3066\u3044\u305f\u3002CS17\u306b\u304a\u3044\u3066\u982d\u84cb\u5e95\u9762\uff08\u56f3\uff12\u70b9\u7dda\uff09\u3088\u308a\u3082\u982d\u5074\u306b\u4f4d\u7f6e\u3057\u3066\u3044\u305f\u773c\u7403\u306f\u3001CS18\u4ee5\u964d\u306f\u5c3e\u5074\u306b\u4f4d\u7f6e\u3057\u3001\u982d\u84cb\u5e95\u9762\u306b\u5bfe\u3057\u3066\u5c3e\u5074\u3092\u5411\u304f\u3088\u3046\u306b\u79fb\u52d5\u3057\u3066\u3044\u305f\u3002CS16\uff5eCS19\u3067\u306e\u524d\u8133\u306e\u6210\u9577\u306b\u4f34\u3044\u3001\u8996\u899a\u5668\u304c\u5c3e\u5074\u3078\u79fb\u52d5\u3057\u3001\u4e2d\u9854\u9762\uff08\u9f3b\u9686\u8d77\u3001\u4e0a\u984e\u306a\u3069\u306e\u8996\u899a\u5668\u306e\u5468\u8fba\u5668\u5b98\uff09\u306e\u6210\u9577\u306b\u3088\u308a\u80ce\u5150\u671f\u306b\u4f4d\u7f6e\u306f\u6c7a\u5b9a\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u308b\u3002<\/p>\n\n\n

\n
\"\"
\u56f3\uff13\u982d\u90e8\u6a2a\u5f84\u3001\u6c34\u6676\u4f53\u9593\u5f84\u3001\u5185\u5074\u30fb\u5916\u5074\u773c\u7403\u9593\u5f84\u306e\u5909\u5316<\/figcaption><\/figure>\n<\/div>\n\n\n

\u3000\u982d\u90e8\u6a2a\u5f84\u3001\u6c34\u6676\u4f53\u9593\u5f84\u3001\u5916\u5074\u30fb\u5185\u5074\u773c\u7403\u9593\u5f84\u5024\u306f\u982d\u6bbf\u9577\u306e\u5897\u52a0\u306b\u6bd4\u4f8b\u3057\u3066\u76f4\u7dda\u7684\u306b\u5897\u5927\u3057\u305f(\u56f3\uff13A)\u3002\u982d\u90e8\u6a2a\u5f84\u306b\u5bfe\u3059\u308b\u6c34\u6676\u4f53\u9593\u8ddd\u96e2\u306e\u6bd4\u306f\uff5eCRL30\u339c\u524d\u5f8c\u306e\u80ce\u5150\u671f\u521d\u671f\u306b\u304b\u3051\u3066\u6025\u6fc0\u306b\u6e1b\u5c11\u3057\u3066\u3044\u305f\u304c\u3001CRL40\u339c\u4ee5\u964d\u306e\u80ce\u5150\u671f\u521d\u671f\u3067\u306f\u5909\u5316\u304c\u3042\u307e\u308a\u307f\u3089\u308c\u306a\u304f\u306a\u308a\u30010.4\uff5e0.5\u306b\u53ce\u675f\u3057\u305f(\u6210\u4eba\u306f\u7d040.48)(\u56f3\uff13B)\u3002\u5185\u5074\/\u5916\u5074\u773c\u7403\u9593\u5f84\u3082CRL40mm\u4ee5\u964d\u306e\u80ce\u5150\u671f\u3067\u306f\u3042\u307e\u308a\u5909\u5316\u304c\u307f\u3089\u308c\u306a\u304f\u306a\u308a0.4\uff5e0.5\u306b\u53ce\u675f\u3057\u305f(\u56f3\uff13C)\u3002\u773c\u7403\u306e\u4f4d\u7f6e\u306e\u79fb\u52d5\u3082\u89e3\u5256\u5b66\u7684\u9818\u57df\u304c\u6210\u9577\u3059\u308b\u306a\u304b\u3067\u3001\u305d\u308c\u305e\u308c\u306e\u4f4d\u7f6e\u95a2\u4fc2\u304c\u5909\u5316\u3057\u4f4d\u7f6e\u304c\u6c7a\u5b9a\u3055\u308c\u3066\u3044\u304f(differential growth)\u306e\u7d50\u679c\u3067\u8aac\u660e\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/h5>\n\n\n
\n
\"\"<\/figure>\n<\/div>\n\n\n

Gasser RT. Evidence that some events of mammalian embryogenesis can result from differential growth, making migration unnecessary, Anat Rec B New Anat,289,53\u201363,2006.<\/p>\n\n\n\n

Kagurasho M et al. Movement of the external ear in human embryo, Head Face Med.8, 2, 2012.<\/p>\n\n\n\n

Osaka M et al. Positional changes of the ocular organs during craniofacial development, Anat Rec, 2017, in press.<\/p>\n\n\n\n

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