{"id":7540,"date":"2021-08-13T14:26:36","date_gmt":"2021-08-13T05:26:36","guid":{"rendered":"http:\/\/www.hs-kyoto.net\/?page_id=7540"},"modified":"2022-12-25T08:00:39","modified_gmt":"2022-12-24T23:00:39","slug":"%e8%84%b3%e3%81%ae%e7%99%ba%e7%94%9f","status":"publish","type":"page","link":"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/?page_id=7540","title":{"rendered":"\u8133\u306e\u5f62\u6210"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">\u8133\u795e\u7d4c\u7ba1\u306e\u5f62\u6210<\/h4>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><a href=\"http:\/\/www.hs-kyoto.net\/?attachment_id=7679\" rel=\"attachment wp-att-7679\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"244\" src=\"http:\/\/www.hs-kyoto.net\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-9.54.39-400x244.png\" alt=\"\" class=\"wp-image-7679\" srcset=\"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-9.54.39-400x244.png 400w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-9.54.39-610x372.png 610w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-9.54.39-115x70.png 115w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-9.54.39-768x468.png 768w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-9.54.39-150x91.png 150w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-9.54.39.png 1043w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><figcaption class=\"wp-element-caption\">\u30b9\u30c6\u30fc\u30b813\u304b\u308923\u306e\u8133\u5ba4\u3092\u900f\u660e\u306a\u8133\u5b9f\u8cea\u3068\u3068\u3082\u306b\u7acb\u4f53\u5316\u3057\u305f\u3002<br>\u30b9\u30c6\u30fc\u30b818\u4ee5\u964d\u3067\u6a4b\u3084\u5ef6\u9ac4\u3001\u5c0f\u8133\u3068\u601d\u308f\u308c\u308b\u90e8\u4f4d\u306e\u767a\u9054\u3068\u3068\u3082\u306b\u6a4b\u5c48\u304c\u8457\u660e\u306b\u5927\u304d\u304f\u306a\u3063\u3066\u3044\u308b\u306e\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<br>\u30b9\u30c6\u30fc\u30b815\u306e\u767a\u751f\u4ee5\u964d\u3001\u98a8\u8239\u306e\u3088\u3046\u306b\u81a8\u3089\u3093\u3067\u3044\u305f\u5927\u8133\u304c\u5927\u8133\u57fa\u5e95\u6838\u3068\u601d\u308f\u308c\u308b\u90e8\u4f4d\u306e\u767a\u9054\u3068\u3068\u3082\u306b\u8133\u5ba4\u3092\u6247\u5f62\u306b\u9665\u51f9\u3055\u305b\u3066\u3044\u304f\u69d8\u5b50\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<\/figcaption><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><a href=\"http:\/\/www.hs-kyoto.net\/?attachment_id=7756\" rel=\"attachment wp-att-7756\"><img loading=\"lazy\" decoding=\"async\" width=\"396\" height=\"300\" src=\"http:\/\/www.hs-kyoto.net\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-13.11.01-396x300.png\" alt=\"\" class=\"wp-image-7756\" srcset=\"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-13.11.01-396x300.png 396w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-13.11.01-610x462.png 610w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-13.11.01-115x87.png 115w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-13.11.01-768x581.png 768w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-13.11.01-150x114.png 150w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-13.11.01-400x303.png 400w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-16-13.11.01.png 967w\" sizes=\"auto, (max-width: 396px) 100vw, 396px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p>\u30d2\u30c8\u306f\u9ad8\u6b21\u8133\u6a5f\u80fd\u3092\u6301\u3064\u751f\u7269\u3067\u3042\u308a\u3001\u3053\u308c\u306f\u4ed6\u306e\u751f\u7269\u3068\u3092\u533a\u5225\u3059\u308b\u6700\u5927\u306e\u7279\u5fb4\u3068\u8a00\u3048\u308b\u3002\u305d\u306e\u305f\u3081\u80da\u5b50\u671f\u306e\u8133\u306e\u767a\u751f\u904e\u7a0b\u306b\u3064\u3044\u3066\u306f\u591a\u304f\u306e\u7814\u7a76\u8005\u304c\u8208\u5473\u3092\u6301\u3063\u3066\u304d\u305f\u3002\u30d2\u30c8\u8133\u795e\u7d4c\u306e\u767a\u751f\u306f\u8907\u96d1\u3067\u3042\u308b<span class=\"s1\">8,9<\/span>\u3002\u8133\u306f\u3001CS \u7d048,9\uff08\u53d7\u7cbe\u5f8c\u7d0417 \u304b\u308919 \u65e5\uff09\u306b\u795e\u7d4c\u7ba1\u3001\u4f53\u7bc0\u304c\u751f\u3058\u59cb\u3081\u308b\u3002\u958b\u304b\u308c\u305f\u795e\u7d4c\u5b54\u306b\u795e\u7d4c\u5206\u7bc0\u304c\u751f\u3058\u59cb\u3081\u3001\u8133\u795e\u7d4c\u7ba1\u9818\u57df\u304c\u533a\u5206\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u3002\u305d\u306e\u5f8c\u3001CS11\u300112\uff08\u53d7\u7cbe\u5f8c\u7d0423 \u304b\u308930 \u65e5\uff09\u306b\u795e\u7d4c\u7ba1\u304c\u3001\u982d\u90e8\u3001\u5c3e\u90e8\u3068\u3082\u306b\u9589\u9396\u3057\u3001\u4f53\u7bc0\u6570\u3082\u7d0421 \u304b\u308929 \u3068\u5897\u52a0\u3059\u308b\u3002\u3053\u306e\u9803\u3001\u982d\u90e8\u306e\u795e\u7d4c\u7ba1\u306b\u3001\u982d\u5074\u304b\u3089\u9806\u306b\u524d\u8133\u3001\u4e2d\u8133\u3001\u83f1\u8133\u3068\u547c\u3070\u308c\u308b\u8133\u80de\u304c\u3067\u304d\u59cb\u3081\u3001\u524d\u8133\u306f\u9593\u8133\u3068\u7d42\u8133\u306b\u533a\u52062\u3055\u308c\u308b\u3002CS14,15\uff08\u53d7\u7cbe\u5f8c\u7d0431 \u304b\u308938 \u65e5\uff09\u306b\u7d42\u8133\u306f\u3001\u5927\u304d\u304f\u306a\u308a\u5de6\u53f32 \u3064\u306e\u534a\u7403\u3068\u8a8d\u8b58\u3067\u304d\u3001\u83f1\u8133\u306f\u3001\u5f8c\u8133\u3068\u9ac4\u8133\u306b\u533a\u5206\u3055\u308c\u308b\u3002\u8133\u306e\u5404\u90e8\u5206\u306f\u3001\u9020\u5f62\u904b\u52d5\u3092\u7d4c\u3066\u767a\u751f\u304c\u9032\u3093\u3067\u3044\u304f\u3002 CS17\uff08\u53d7\u7cbe\u5f8c\u7d0442 \u304b\u308944 \u65e5\uff09\u306b\u306a\u308b\u3068\u3001\u7d42\u8133\u306f\u9593\u8133\u3092\u8986\u3044\u59cb\u3081\u3001CS19\uff08\u53d7\u7cbe\u5f8c\u7d0448 \u304b\u308951 \u65e5\uff09\u306b\u306a\u308b\u3068\u543b\u65b9\uff08\u982d\u5074\u65b9\u5411\uff09\u306b\u5927\u304d\u304f\u306a\u308b\u3002CS23\uff08\u53d7\u7cbe\u5f8c\u7d0456 \u304b\u308960 \u65e5\uff09\u306b\u306f\u7d42\u8133\u306f\u9593\u8133\u5168\u4f53\u3092\u8986\u3044\u5f62\u614b\u7684\u306b\u3082\u6e7e\u66f2\u3057\u3066C \u306e\u5f62\uff08C-shape\uff09\u304c\u306f\u3063\u304d\u308a\u3068\u89b3\u5bdf\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308b\u3002\u80ce\u5150\u671f\u306b\u306a\u308b\u3068\u3001\u7d049 \u9031\u3067\u8133\u534a\u7403\u306e\u8868\u9762\u306f\u65b0\u76ae\u8cea\u3068\u306a\u308a\u300113 \u9031\u307e\u3067\u306b\u306f\u6025\u901f\u306b\u80cc\u5074\u306b\u5927\u304d\u304f\u306a\u308a\u80da\u5b50\u671f\u306e\u7d043 \u500d\u3082\u306e\u5bb9\u7a4d\u3068\u306a\u308b\u3002\u4e2d\u8133\u304c\u8986\u308f\u308c\u3001\u8133\u534a\u7403\u306e\u5b9f\u8cea\u90e8\u5206\u3067\u3042\u308b\u65b0\u76ae\u8cea\u304c\u767a\u9054\u3057\u3001\u5074\u8133\u5ba4\u306e\u5bb9\u7a4d\u304c\u5c11\u306a\u304f\u306a\u308b<span class=\"s1\">8,10<\/span>\u3002\u51fa\u751f\u5f8c\u3001\u7d42\u8133\u306f\u5927\u8133\u534a\u7403\u3001\u5f8c\u8133\u306f\u5c0f\u8133\u306b\u3001\u9ac4\u8133\u306f\u5ef6\u9ac4\u306b\u305d\u308c\u305e\u308c\u5bfe\u5fdc\u3059\u308b\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">\u5927\u8133\u76ae\u8cea\u306e\u767a\u751f<\/h4>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft is-resized\"><a href=\"http:\/\/www.hs-kyoto.net\/?attachment_id=7552\" rel=\"attachment wp-att-7552\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.hs-kyoto.net\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.36.12-300x217.png\" alt=\"\" class=\"wp-image-7552\" width=\"400\" height=\"289\" srcset=\"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.36.12-300x217.png 300w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.36.12-610x441.png 610w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.36.12-115x83.png 115w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.36.12-768x555.png 768w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.36.12-150x108.png 150w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.36.12-400x289.png 400w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.36.12.png 1195w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p>\u30d2\u30c8\u5927\u8133\u65b0\u76ae\u8cea\u306f\u6210\u4eba\u306b\u304a\u3044\u30666\u5c64\u69cb\u9020\u3092\u6210\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u5c64\u69cb\u9020\u306e\u767a\u9054\u306fCarnegie Stage (CS)14\u306b\u304a\u3044\u3066Ventricular zone (VZ)\u306e\u5916\u5074\u306bPreplate (PP)\u3068\u3044\u3046\u5c64\u304c\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u304b\u3089\u958b\u59cb\u3059\u308b(O\u2019Rahilly and M\u00fcller, 2006)\u3002\u305d\u3057\u3066CS21\u9803\u306b\u306a\u308b\u3068PP\u5185\u306bCortical plate (CP)\u304c\u5f62\u6210\u3055\u308c\u308b\u3002CP\u304cPP\u3092\u5206\u65ad\u3059\u308b\u3053\u3068\u3067\u5185\u5074\u306bSubplate layer (SP)\u304c\u5f62\u6210\u3055\u308c\u308b\u3002\u3064\u307e\u308a\u3001\u5927\u8133\u5b9f\u8cea\u306f\u8133\u5ba4\u5074\u3088\u308a\u5927\u304d\u304f\u5206\u3051\u3066VZ, Subventricular zone (SVZ), Intermediate zone (IZ), SP, CP\u306e5\u5c64\u69cb\u9020\u3092\u3001\u8edf\u819c\u4e0b\u5c64\u306a\u3069\u3092\u542b\u3081\u308b\u3068\u305d\u308c\u4ee5\u4e0a\u306e\u5c64\u69cb\u9020\u3092\u3068\u308b\u3088\u3046\u306b\u306a\u308b\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u5f8c\u65b0\u76ae\u8cea\u306fVZ\u304b\u3089\u795e\u7d4c\u7d30\u80de\u304c\u5916\u5074\u3078\u5411\u3051\u3066\u653e\u5c04\u72b6\u306b\u79fb\u52d5\u3057\u3001CP\u304c\u539a\u307f\u3092\u5897\u3059\u3053\u3068\u3067\u5f62\u6210\u3055\u308c\u3066\u3044\u304f(Rakic et al., 1974; Ohtaka-Maruyama et al., 2015)\u3002SP\u306f\u3053\u306e\u795e\u7d4c\u7d30\u80de\u306e\u6b63\u5e38\u306a\u79fb\u52d5\u306b\u95a2\u4e0e\u3059\u308b\u30b5\u30d6\u30d7\u30ec\u30fc\u30c8\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u4fdd\u6301\u3059\u308b\u91cd\u8981\u306a\u5c64\u3067\u3042\u308a\u3001\u9032\u5316\u306e\u904e\u7a0b\u306b\u304a\u3044\u3066\u65b0\u76ae\u8cea\u3068\u540c\u69d8\u3001\u54fa\u4e73\u985e\u306e\u307f\u6301\u3064\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b(Ohtaka-Maruyama et al., 2018)\u3002\u307e\u305fSP\u306e\u6b20\u5982\u306f\u7d71\u5408\u5931\u8abf\u75c7\u3084\u81ea\u9589\u75c7\u306a\u3069\u306e\u767a\u9054\u7570\u5e38\u306b\u95a2\u308f\u308b\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b(A. Hoerder-Suabedissen et al., 2013) \u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">\u30b5\u30d6\u30d7\u30ec\u30fc\u30c8\u3068\u306f<\/h4>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft is-resized\"><a href=\"http:\/\/www.hs-kyoto.net\/?attachment_id=7555\" rel=\"attachment wp-att-7555\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.hs-kyoto.net\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.40.37-300x202.png\" alt=\"\" class=\"wp-image-7555\" width=\"400\" height=\"269\" srcset=\"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.40.37-300x202.png 300w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.40.37-610x410.png 610w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.40.37-115x77.png 115w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.40.37-768x516.png 768w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.40.37-150x101.png 150w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.40.37-400x269.png 400w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.40.37.png 1042w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p>Kostovic and Rakic (1990)\u306f8~28\u9031\u306e\u80ce\u5150\u306e\u7d44\u7e54\u3092\u89b3\u5bdf\u3057\u3001SP\u306e\u767a\u751f\u521d\u671f\u3067\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u305f12\u9031\u524d\u5f8c\u304b\u3089\u3001\u6700\u5f8c\u306b\u89b3\u5bdf\u3055\u308c\u308b\u3068\u3044\u3046\u751f\u5f8c6\u304b\u6708\u307e\u3067\u30924\u3064\u306e\u904e\u7a0b\u306b\u5206\u985e\u3057\u305f\u3002\u6700\u521d\u306e\u904e\u7a0b\u3092Presubplate stage\u3068\u3057\u3001\u4f53\u6027\u611f\u899a\u91ce\u3068\u8996\u899a\u91ce\u306b\u304a\u3044\u3066\u89b3\u5bdf\u3092\u884c\u3063\u305f\u3002\u3069\u3061\u3089\u306e\u7d44\u7e54\u306b\u304a\u3044\u3066\u3082\u7d30\u80de\u306e\u5bc6\u96c6\u3057\u305fCP\u306e\u4e0b\u306b\u67d3\u8272\u6027\u306e\u8584\u3044\u3001\u5375\u5186\u7cfb\u306e\u6838\u3092\u6301\u3063\u305f\u5c11\u6570\u306e\u7d30\u80de\u4f53\u3092\u542b\u3080\u539f\u59cb\u7684\u306aSP\u304c\u898b\u3089\u308c\u305f\u3002SP\u5185\u306b\u306f\u3059\u3067\u306b\u8ef8\u7d22\u3084\u6a39\u72b6\u7a81\u8d77\u304c\u8c4a\u5bcc\u306b\u898b\u3089\u308c\u305f\u3002IZ\u3068\u306e\u5883\u754c\u306f\u4f53\u6027\u611f\u899a\u91ce\u3088\u308a\u3082\u8996\u899a\u91ce\u306b\u304a\u3044\u3066\u3088\u308a\u306f\u3063\u304d\u308a\u898b\u3089\u308c\u305f\u3002\u307e\u305f\u300114\u9031\u4ee5\u964d\u306e\u4ee3\u8868\u500b\u4f53\u306b\u304a\u3044\u3066\u4e8c\u6b21\u5143\u7684\u306b\u5207\u7247\u4e0a\u306e\u9577\u3055\u3092\u8a08\u6e2c\u3059\u308b\u3053\u3068\u3067SP\u306e\u539a\u3055\u5909\u5316\u306e\u691c\u8a0e\u3092\u884c\u3063\u305f\u3002\u307e\u305f\u80da\u5b50\u671f\u7d42\u671f\u3067\u306fCS21~23\u306e\u30b9\u30c6\u30fc\u30b8\u30f3\u30b0\u306b\u5f93\u3063\u305f\u7d44\u7e54\u5207\u7247\u306e\u8a73\u3057\u3044\u89b3\u5bdf\u3082\u884c\u308f\u308c\u3066\u3044\u305f(O\u2019Rahilly and M\u00fcller, 2006)\u3002CS21\u3067CP\u304c\u3067\u304d\u308b\u3053\u3068\u306b\u3088\u308a\u5c64\u69cb\u9020\u304c\u78ba\u8a8d\u3067\u304d\u3001CS23\u306b\u306a\u308b\u3068\u7279\u306b\u6210\u4eba\u3067\u5cf6\u76ae\u8cea\u3068\u306a\u308b\u9818\u57df\u306b\u660e\u767d\u306b\u898b\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002CP\u306fVZ\u304b\u3089\u653e\u5c04\u72b6\u306b\u79fb\u52d5\u3057\u305f5\u5217\u4ee5\u4e0a\u306e\u7d30\u80de\u306e\u4e26\u3073\u304b\u3089\u306a\u3063\u3066\u3044\u305f\u3002SP\u306f\u7d30\u80de\u306e\u4e4f\u3057\u3055\u3068\u63a5\u7dda\u65b9\u5411\u306b\u4f38\u3073\u308b\u795e\u7d4c\u7dda\u7dad\u3092\u7279\u5fb4\u3068\u3059\u308b\u5c64\u3067\u3042\u3063\u305f\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h5 class=\"wp-block-heading\">\u5cf6\u76ae\u8cea\u3068\u306f<\/h5>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft is-resized\"><a href=\"http:\/\/www.hs-kyoto.net\/?attachment_id=7558\" rel=\"attachment wp-att-7558\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.hs-kyoto.net\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.45.55-300x216.png\" alt=\"\" class=\"wp-image-7558\" width=\"400\" height=\"288\" srcset=\"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.45.55-300x216.png 300w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.45.55-610x440.png 610w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.45.55-115x83.png 115w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.45.55-768x553.png 768w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.45.55-150x108.png 150w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.45.55-400x288.png 400w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2021-08-13-12.45.55.png 1038w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p>\u76ae\u8cea\u306e\u9818\u57df\u306e\u4e00\u3064\u3067\u6210\u4eba\u3067\u306f\u5916\u5074\u6e9d\u306e\u5965\u306b\u3042\u308b<\/p>\n\n\n\n<p>\u60c5\u52d5\u306a\u3069\u306e\u8a8d\u77e5\u6a5f\u80fd\u3001\u5473\u899a\u55c5\u899a\u89e6\u899a\u75db\u899a\u306a\u3069\u306b\u95a2\u4e0e<\/p>\n\n\n\n<p>CS23\u9803\u306b\u5074\u982d\u90e8\u306b\u51fa\u73fe<\/p>\n\n\n\n<div style=\"height:1px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h5 class=\"wp-block-heading\">\u5c0f\u8133\u306e\u5f62\u6210<\/h5>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.hs-kyoto.net\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.32.36-610x332.png\" alt=\"\" class=\"wp-image-11478\" width=\"400\" height=\"218\" srcset=\"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.32.36-610x332.png 610w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.32.36-400x218.png 400w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.32.36-115x63.png 115w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.32.36-768x418.png 768w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.32.36-1536x837.png 1536w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.32.36-150x82.png 150w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.32.36.png 1612w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.hs-kyoto.net\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.33.29-610x280.png\" alt=\"\" class=\"wp-image-11480\" width=\"400\" height=\"184\" srcset=\"http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.33.29-610x280.png 610w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.33.29-400x183.png 400w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.33.29-115x53.png 115w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.33.29-768x352.png 768w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.33.29-1536x704.png 1536w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.33.29-150x69.png 150w, http:\/\/pathology.hs.med.kyoto-u.ac.jp\/wp-content\/uploads\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2022-12-25-7.33.29.png 1806w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u8133\u795e\u7d4c\u7ba1\u306e\u5f62\u6210 \u30d2\u30c8\u306f\u9ad8\u6b21\u8133\u6a5f\u80fd\u3092\u6301\u3064\u751f\u7269\u3067\u3042\u308a\u3001\u3053\u308c\u306f\u4ed6\u306e\u751f\u7269\u3068\u3092\u533a\u5225\u3059\u308b\u6700\u5927\u306e\u7279\u5fb4\u3068\u8a00\u3048\u308b\u3002\u305d\u306e\u305f\u3081\u80da\u5b50\u671f\u306e\u8133\u306e\u767a\u751f\u904e\u7a0b\u306b\u3064\u3044\u3066\u306f\u591a\u304f\u306e\u7814\u7a76\u8005\u304c\u8208\u5473\u3092\u6301\u3063\u3066\u304d\u305f\u3002\u30d2\u30c8\u8133\u795e\u7d4c\u306e\u767a\u751f\u306f\u8907\u96d1\u3067\u3042\u308b8,9\u3002\u8133\u306f\u3001CS \u7d048, 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